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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Composition and bioactivity of the leaf essential oil of Heteropyxis dehniae from Zimbabwe
Journal of Ethnopharmacology, Volume 92, No. 1, Year 2004
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Description
The leaf oil of Heteropyxis dehniae Suess. (Heteropyxidaceae) was obtained by hydrodistillation and analyzed by GC/MS. The most abundant essential oil components are linalool (58.3%), 4-terpineol (9.8%), α-terpineol (3.6%), and caryophyllene oxide (3.1%). The antimicrobial activity against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and Aspergillus niger, and the in vitro cytotoxicity of the oil on PC-3, MDA-MB-231, Hs 578T, MCF7, SK-MEL-28, and 5637 human tumor cells were also examined. Caryophyllene oxide shows notable cytotoxic activity with LC 50 values of 147-351μM. © 2004 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Sibanda, Samson
Zimbabwe, Harare
University of Zimbabwe
Zimbabwe, Bulawayo
National University of Science and Technology Bulawayo
Chigwada, Grace
Zimbabwe, Harare
University of Zimbabwe
Poole, Melvin
United States, Huntsville
Oakwood University
Gwebu, Ephraim Tobela
United States, Huntsville
Oakwood University
United States, Elizabeth City
Elizabeth City State University
Noletto, Joseph A.
United States, Huntsville
The University of Alabama in Huntsville
Schmidt, Jennifer M.
United States, Huntsville
The University of Alabama in Huntsville
Rea, Angela I.
United States, Huntsville
The University of Alabama in Huntsville
Setzer, William N.
United States, Huntsville
The University of Alabama in Huntsville
Statistics
Citations: 119
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1016/j.jep.2004.02.010
ISSN:
03788741
Research Areas
Cancer
Study Locations
Niger
Zimbabwe