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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Biomarkers and early detection of late onset anthracycline-induced cardiotoxicity in children
Hematology, Volume 17, No. 3, Year 2012
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Description
Background: The main strategy for minimizing anthracycline cardiotoxicity is early detection of high-risk patients. Aim of the study: To investigate the role of cardiac biomarkers; cardiac troponin T (cTnT) and N-terminal probrain natriuretic peptide (NT-pro-BNP), and tissue Doppler imaging (TDI), as early predictors of chronic cardiotoxicity in survivors of acute leukemia. Patients and methods: We carried a retrospective study on 50 asymptomatic survivors of acute leukemia who received anthracycline in their treatment protocols. All patients underwent blood sampling to determine the levels of NT-pro-BNP and cTnT along with conventional echocardiography and TDI. Results: None had abnormal cTnT levels. About 20% had abnormal NT-pro-BNP levels. Diastolic dysfunction of the left ventricle was the most significant in conventional echocardiography. TDI was superior as it detected myocardial affection in 10% more than echo. TDI demonstrated global myocardial damage with significant aberrations in peak myocardial velocities and ratios. Conclusions: NT-pro-BNP can be used as a sensitive cardiac biomarker in monitoring of anthracyclineinduced cardiotoxicity. Follow up is essential to validate the role of NT-pro-BNP as an early marker for late onset anthracycline-induced cardiotoxicity. Tissue Doppler is marvelous as it could detect early cardiac dysfunction even in those with normal study by conventional echocardiography. © W.S. Maney & Son Ltd 2012.
Authors & Co-Authors
Sherief, Laila Metwaly
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Kamal, Ahmad G.
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Khalek, E. A.
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Kamal, Naglaa M.
Egypt, Cairo
Faculty of Medicine
Soliman, Attia Abdelwehab A.
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Esh, Asmaa Mohamed Husny
Egypt, Zagazig
Faculty of Veterinary Medicine
Statistics
Citations: 52
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1179/102453312X13376952196412
ISSN:
10245332
e-ISSN:
16078454
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cohort Study