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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High prevalence of occult hepatitis B in hepatitis C-infected Egyptian children with haematological disorders and malignancies
Liver International, Volume 29, No. 4, Year 2009
Notification
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Description
Objective: This study investigates the prevalence of occult hepatitis B virus (HBV) in children and adolescents with haematological diseases with or without hepatitis C virus (HCV) infection. Methods: Forty-nine children with haematological disorders (median age 11.4 years) and 51 with haematological malignancies (median age 8 years) were enrolled. Sera were tested for HCV antibodies, HCV-RNA [nested reverse transcriptase polymerase chain reaction (PCR)], HBV markers (HBsAg, anti-HBcAb IgM and total, HBeAg) and HBV-DNA (nested PCR for s, c and x regions). Results: Anti-HCV was detected among 40/49 (81.6%) children with haematological disorders (24/49; 49% HCV-RNA positive) and 9/51 (17.6%) children with malignancies (12/51; 23.5% HCV-RNA positive). HBV-DNA was positive among 38%; positive c region in 33% (15/49 and 18/51 children with haematological disorders and malignancies respectively), s region in four leukaemics and x region in one leukaemic. Twenty-one patients had occult HBV infection; one (2.6%) was HBeAg positive, four (19%) total HBcAb positive, 20 (95.2%) c region HBV-DNA positive and one was s region positive (1/21; 4.8%). HCV-RNA was the significant predictor for occult HBV (P < 0.05), with an increased frequency of HBV-DNA in the HBsAg negative (HCV-RNA positive) (63.2%) compared with patients negative for HCV-RNA (25%) (P = 0.009). Conclusion: Occult HBV infection is not uncommon in transfused immunocompromised children with chronic HCV infection. Nucleic acid amplification should be considered in screening donors as post-transfusion hepatitis B viraemia may be substantial. © 2009 The Authors. Journal compilation © 2009 Blackwell Publishing Ltd.
Authors & Co-Authors
Said, Zeinab N.
Egypt, Cairo
Faculty of Medicine
El-Sayed, Manal Hamdy
Egypt, Cairo
Ain Shams University
El-Bishbishi, Iman A.
Egypt, Cairo
The Biological Center for Diagnostic Products
El-Fouhil, Daad F.
Egypt, Cairo
Faculty of Medicine
Abdel-Rheem, Soad E.
Egypt, Cairo
Faculty of Medicine
El-Abedin, Maha Z.
Egypt, Cairo
Faculty of Medicine
Salama, I. I.
Egypt, Giza
National Research Centre
Statistics
Citations: 40
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1111/j.1478-3231.2009.01975.x
ISSN:
14783223
e-ISSN:
14783231
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study