Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Simplified experimental cerebral aneurysm model in rats: Comprehensive evaluation of induced aneurysms and arterial changes in the circle of Willis
Brain Research, Volume 1300, Year 2009
Notification
URL copied to clipboard!
Description
Establishing a simple and comprehensive experimental model is one of the most important issues in the study of cerebral aneurysms. Previous models in the rat required two stage surgeries and observations were limited to a few branching sites. The present study aimed to introduce a simplified model in rats and to provide a comprehensive evaluation of induced arterial changes in the circle of Willis. Sprague-Dawley rats underwent ligation of the right common carotid artery, and posterior and inferior (group 2, n = 9) or only posterior (group 3, n = 12) branches of the bilateral renal arteries, and bilateral oophorectomy. Dahl salt-sensitive rats underwent only carotid ligation and bilateral oophorectomy (group 5, n = 11). All surgical procedures were completed in one procedure instead of two in the original method. Salt loading was started after the surgery. Five rats of each strain without treatment served as controls (groups 1 and 4, respectively). Three months later, vascular corrosion casts of the cerebral arteries were examined by scanning electron microscopy. Experimental rats in groups 2, 3, and 5 developed 43 aneurysmal lesions at branching sites. Forty-eight arterial changes including dilatation, tortuosity, and fusiform or lateral wall aneurysms were observed at non-branching sites. Group 3 appeared to be superior to the other groups for experimental studies. The frequency and degree of the induced lesions were comparable with previous studies even after the surgical simplification. The present model may be more practical for the study of experimental cerebral aneurysms. © 2009 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Eldawoody, Hany A.Fikry
Japan, Sendai
Graduate School of Medicine
Egypt, Mansoura
Faculty of Medicine
Shimizu, Hiroaki
Japan, Sendai
Graduate School of Medicine
Kimura, Naoto
Japan, Sendai
Graduate School of Medicine
Saito, Atsushi
Japan, Sendai
Graduate School of Medicine
Nakayama, Toshio
Japan, Sendai
Graduate School of Medicine
Japan, Sendai
Tohoku University
Takahashi, Akira
Japan, Sendai
Graduate School of Medicine
Japan, Sendai
Tohoku University
Tominaga, Teiji
Japan, Sendai
Graduate School of Medicine
Statistics
Citations: 19
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.brainres.2009.08.099
ISSN:
00068993
Research Areas
Health System And Policy