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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Molecular epidemiology of rotavirus in four provinces of Angola before vaccine introduction
Journal of Medical Virology, Volume 88, No. 9, Year 2016
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Description
Angola is a sub-Saharan country in southern Africa highly affected by diarrhoeal disease with limited epidemiological data regarding etiologic agents. This study was performed during 2012–2013, prior to rotavirus vaccine introduction, with the objective to detect and characterize the rotavirus strains circulating in four provinces of the country: Huambo, Luanda, Zaire, and Cabinda. A high rotavirus detection rate (35%, 117/334) was observed. G1 was the most common G-genotype (83.6%), whereas P[8] (50.9%) followed by P[6] (38.8%) were the most common P-types. G1P[8] was identified as the predominant combination (50%), followed by the unusual G1P[6] (29.3%). Strains such G2P[4], G8P[6], G9P[6], and G12P[6] were also found in lower frequencies (5.2–1.7%). The P[6] strains did not cluster in the phylogenetic trees according to their geographic origin or even the corresponding G-genotype, suggesting a limited number of recent introductions and extensive reassortment events. Our results represent the first report on rotavirus genotype profiles in Angola, showing a wide circulation of the unusual genotype G1P[6], and underline the importance of RV surveillance after the vaccine introduction. J. Med. Virol. 88:1511–1520, 2016. © 2016 Wiley Periodicals, Inc.
Authors & Co-Authors
Esteves, Aida
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Nordgren, Johan
Sweden, Linkoping
Linköpings Universitet
Pereira, Joana
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Fortes, Fabiane Silva A.
Angola, Luanda
National Malaria Control Programme
Dimbu, Pedro Rafael
Angola, Luanda
National Malaria Control Programme
Saraiva, Nilton
Angola, Luanda
National Malaria Control Programme
Mendes, Cristina
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Istrate, Claudia
Portugal, Lisbon
Instituto de Higiene e Medicina Tropical
Statistics
Citations: 10
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1002/jmv.24510
ISSN:
01466615
e-ISSN:
10969071
Research Areas
Genetics And Genomics
Study Locations
Angola