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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Impact of a functional KIR2DS4 allele on heterosexual HIV-1 transmission among discordant Zambian couples
Journal of Infectious Diseases, Volume 203, No. 4, Year 2011
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Description
Killer cell immunoglobulin-like receptors (KIRs) and their HLA ligands interact to regulate natural killer (NK) cell function. KIR gene content and allelic variations are reported to influence human immunodeficiency virus (HIV)-1 infection and pathogenesis. We investigated the impact of KIR genes on heterosexual HIV-1 transmission among 566 discordant couples from Lusaka, Zambia. KIR2DS4*001, the only allele of KIR2DS4 known to encode a functional activating receptor, was associated with relatively high viral load for HIV-1 in index (HIV-1 seroprevalent) partners (β [standard error (SE)], .17 [.8] log10; P = .04) and with accelerated transmission of HIV-1 to cohabiting seronegative partners (relative hazard [RH], 2.00; P = .004). The latter association was independent of the direction of transmission (male-to-female or female-to-male), genital ulcers, and carriage of the putative ligand (HLA-Cw*04). No KIR-gene variant in the initially seronegative partners was associated with HIV-1 acquisition or early viral load following seroconversion. Further analysis of NK cell function should clarify the role of KIR2DS4*001 in HIV-1 transmission. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Merino, Aimee
United States, Birmingham
The University of Alabama at Birmingham
Malhotra, Rakhi
United States, Birmingham
The University of Alabama at Birmingham
Morton, Matt
United States, Birmingham
The University of Alabama at Birmingham
Mulenga, Joseph
Zambia, Lusaka
Rwanda Zambia Hiv Research Group
Allen, Susan A.
Zambia, Lusaka
Rwanda Zambia Hiv Research Group
United States, Atlanta
Emory University
Hunter, Eric
United States, Atlanta
Emory University
Tang, Jianming
United States, Birmingham
The University of Alabama at Birmingham
Kaslow, Richard A.
United States, Birmingham
The University of Alabama at Birmingham
Statistics
Citations: 56
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1093/infdis/jiq075
ISSN:
00221899
Research Areas
Environmental
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Study Locations
Zambia
Participants Gender
Male
Female