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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A random phase II study of mitoxantrone and cisplatin in patients with hepatocellular carcinoma: An ECOG study
Cancer, Volume 60, No. 9, Year 1987
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Description
Of 86 patients entered in an Eastern Cooperative Oncology Group (ECOG) random Phase II study of mitoxantrone (DHAD) and cisplatin (DDP) in primary liver cancer, 69 were eligible. Nine of the 13 ineligible patients were excluded after a pathology review. Sixty‐one percent of the patients were North American, and 39% were South African. The most common severe or the worst toxicity on DHAD was hematologic; and to DDP, hematologic and vomiting. Of the 69 eligible patients, 21 experienced severe, life‐threatening or fatal toxic reactions. Two patients treated with DDP had partial responses. With a 95% confidence interval, the true response rate to DHAD was less than 8%, and to DDP, less than 17%. The median survival time was 14 weeks on both drugs. Assuming a proportional hazards model, factors that are significantly associated with survival are patient performance status, the presence of the symptoms, raised bilirubin and hepatomegaly, and clinical evidence of cirrhosis. Any differences between survival rates for South African and North American patients were largely explainable by these factors. Copyright © 1987 American Cancer Society
Authors & Co-Authors
Falkson, Geoffrey G.
South Africa, Pretoria
University of Pretoria
Ryan, Louise M.
United States, Boston
Harvard T.h. Chan School of Public Health
Johnson, Lewis A.
United States, Providence
Brown University
Simson, Ian W.
South Africa, Pretoria
University of Pretoria
Coetzer, Barend Johannes
South Africa, Pretoria
University of Pretoria
Carbone, Paul P.
United States, Madison
University of Wisconsin-madison
Creech, Richard H.
United States, Philadelphia
American Oncologic Hospital
Schutt, Allan J.
United States, Rochester
Mayo Clinic
Statistics
Citations: 82
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1002/1097-0142(19871101)60:9<2141::AID-CNCR2820600903>3.0.CO;2-4
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Environmental
Health System And Policy