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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Comparison of pregnancy outcomes in women with repaired versus unrepaired atrial septal defect
BJOG: An International Journal of Obstetrics and Gynaecology, Volume 116, No. 12, Year 2009
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Description
Objective To compare the risks of complications during pregnancy in women with repaired andunrepaired atrial septal defects (ASDs) without associated complex cardiac lesions. Design A retrospective multicentre study. Setting Tertiary centres in the Netherlands and Belgium. Population Women with ASD without associated complex cardiac lesions. Methods Women were identified using two congenital heart disease registries. One hundred women were identified who had 243 pregnancies, including 49 miscarriages and six terminations of pregnancy. Detailed information on each completed pregnancy (n = 188; unrepaired ASD, n = 133; repaired ASD, n = 55) was obtained using medical records and telephone interviews. In addition, data from the Generation R database (a prospective cohort study; n = 9667) were used to determine the background risk (control group). Main outcome measures Adjusted odds ratios (AORs) for cardiac, obstetric and neonatal events controlled for multiple pregnancies per woman using general estimating equation analysis. Results Women with an unrepaired ASD had a higher risk of neonatal events (AOR = 2.99, 95% confidence interval [CI] 1.14-7.89, P = 0.027) than women with a repaired ASD. The risk of cardiac and obstetric complications was comparable between women with unrepaired and repaired ASDs. Compared with the general population, women with an unrepaired ASD had higher risks of pre-eclampsia (AOR = 3.54, 95% CI 1.26-9.98, P = 0.017), small-for-gestational-age births (AOR = 1.95, 95% CI 1.15-3.30, P = 0.013) and fetal mortality (AOR = 5.55, 95% CI 1.77-17.4, P = 0.003). By contrast, no differences were observed when comparing women with a repaired ASD versus controls. Conclusions Women with an unrepaired ASD are at increased risk of neonatal events in comparison with women with a repaired ASD. Compared with the general population, women with an unrepaired ASD are at increased risk of pre-eclampsia, small-for-gestational-age births and fetal mortality. © RCOG 2009 BJOG An International Journal of Obstetrics and Gynaecology.
Authors & Co-Authors
Meijboom, Folkert Jan
Netherlands, Rotterdam
Erasmus Mc
Moons, Philip
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Mulder, Barbara J.M.
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Vliegen, Hubert W.
Netherlands, Leiden
Leids Universitair Medisch Centrum
van Dijk, Arie P.J.
Netherlands, Nijmegen
Radboud University Medical Center
Jaddoe, Vincent W.V.
Netherlands, Rotterdam
Erasmus Mc
Steegers, Eric A.P.
Netherlands, Rotterdam
Erasmus Mc
Roos-Hesselink, Jolien W.
Netherlands, Rotterdam
Erasmus Mc
Statistics
Citations: 90
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1111/j.1471-0528.2009.02301.x
ISSN:
14710528
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Female