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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Familial and phenotypic associations of the aldosterone renin ratio
Journal of Clinical Endocrinology and Metabolism, Volume 94, No. 11, Year 2009
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Description
Context: The aldosterone to renin ratio (ARR) is a marker of aldosterone excess, widely used to screen for primary aldosteronism (PA). The significance of a raised ARR in normotensive and hypertensive subjects and the phenotypic and familial factors affecting it are unclear. Objective: We estimated the distribution and heritability of the ARR and tested for associations between ARR and blood pressure (BP) with 11 polymorphisms at the CYP11B1/CYP11B2 locus. Design and Setting: A total of 1172 individuals from 248 Caucasian families ascertained via a hypertensive proband were evaluated. Main Outcome Measure: Plasma aldosterone was measured by RIA, and plasma renin concentration was measured by the LIAISON Direct Renin chemiluminescent immunoassay. Results: Unadjusted and adjusted ARR were continuously distributed in normotensives and hypertensives, with no evidence of a cutoff that would identify a separate population with PA. Median ARR was 4.19 ng/liter per mIU/liter (range, 0.04-253.16). ARR levels were higher in females and associated with age, body mass index, and potassium. Antihypertensive agents had significant predictable effects on the ARR. Renin was negatively associated, and ARR was positively associated with ambulatory BP readings (P < 0.001) in subjects not taking antihypertensives. The heritability of the ARR was 38.1% (P < 10 -8). Plasma aldosterone, but not ARR, was influenced by the intron 2 conversion variation in the CYP11B2 gene (β = -0.07; P = 0.04). Conclusions: The ARR is continuously distributed, is influenced by genetic and environmental factors, and is not a marker of a distinct pathological abnormality but possibly reflects the long-term influence of aldosterone on cardiovascular homeostasis. Copyright © 2009 by The Endocrine Society.
Authors & Co-Authors
Alvarez-Madrazo, Samantha
United Kingdom, Glasgow
Glasgow Cardiovascular Research Centre
Padmanabhan, Sandosh
United Kingdom, Glasgow
Glasgow Cardiovascular Research Centre
Mayosi, Bongani M.
South Africa, Observatory
Groote Schuur Hospital
United Kingdom, Oxford
University of Oxford
Watkins, Hugh C.
United Kingdom, Oxford
University of Oxford
Avery, Peter J.
United Kingdom, Newcastle
Newcastle University
Wallace, A. Michael
United Kingdom, Glasgow
Glasgow Royal Infirmary
Fräser, Robert B.
United Kingdom, Glasgow
Glasgow Cardiovascular Research Centre
Davies, Eleanor
United Kingdom, Glasgow
Glasgow Cardiovascular Research Centre
Keavney, Bernard D.
United Kingdom, Newcastle
Newcastle University
Connell, John M.C.
United Kingdom, Glasgow
Glasgow Cardiovascular Research Centre
Statistics
Citations: 42
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1210/jc.2009-1406
ISSN:
0021972X
e-ISSN:
0021972X
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Female