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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Factors influencing intracytoplasmic sperm injection (ICSI) outcome in men with azoospermia
BJU International, Volume 112, No. 2, Year 2013
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Description
What's known on the subject? and What does the study add? The management of patients with non-obstructive azoospermia (NOA) and some cases of obstructive azoospermia involves testicular sperm extraction (TESE or micro-dissection TESE) combined with intracytoplasmic sperm injection (ICSI). Several studies have investigated the effect of the male age, the cause of azoospermia, testicular histopathology, the type of sperm used, and the use of pentoxyphilline, on the ICSI cycle outcome in men with azoospermia. The present study showed that none of these factors influenced the ICSI outcome in men with azoospermia, thus once sperm is found in an azoospermic male, no other male factor seems to influence the ICSI outcome. To our knowledge this is the first study to comment on the outcome of ICSI in men with NOA based on testicular histopathology. Objectives To access the effect of: male age, the cause of azoospermia (obstructive azoospermia vs non-obstructive azoospermia [NOA]), testicular histopathology, the type of sperm used (fresh vs frozen-thawed), and the use of pentoxyphilline on the intracytoplasmic sperm injection (ICSI) cycle outcome in men with azoospermia. To our knowledge this is the first study to comment on the outcome of ICSI in men with NOA based on testicular histopathology. Patients and Methods A retrospective analysis of 137 testicular sperm extraction-ICSI cycles performed between 2001-2010, involving 103 men with azoospermia, with 26 couples having repeat cycles. Results Analysis of the results did not show any statistically significant differences in the fertilization, embryo cleavage, clinical pregnancy, live birth and miscarriage rates in relation to the male age, cuase of azoospermia, testicular histopathology, type of sperm used and the use of pentoxyphilline. Conclusion Once sperm is found in a man with azoospermia, no other male factor seems to influence the ICSI outcome. © 2013 BJU International.
Authors & Co-Authors
Abdel Raheem, Amr
United Kingdom, London
Institute of Urology
Egypt, Cairo
Faculty of Medicine
Rushwan, Nagla
United Kingdom, London
University College London
Garaffa, Giulio
United Kingdom, London
Institute of Urology
Zacharakis, E.
United Kingdom, London
Institute of Urology
Doshi, Alpesh
United Kingdom, London
Centre for Reproductive and Genetic Health
Heath, Carleen
United Kingdom, London
Centre for Reproductive and Genetic Health
Serhal, Paul F.
United Kingdom, London
Centre for Reproductive and Genetic Health
Harper, Joyce Catherine
United Kingdom, London
University College London
United Kingdom, London
Centre for Reproductive and Genetic Health
Christopher, Nim A.
United Kingdom, London
Institute of Urology
Ralph, David J.
United Kingdom, London
Institute of Urology
Statistics
Citations: 30
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1111/j.1464-410X.2012.11714.x
ISSN:
14644096
e-ISSN:
1464410X
Research Areas
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Male