Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion
Cell Host and Microbe, Volume 12, No. 5, Year 2012
Notification
URL copied to clipboard!
Description
Salmonella Typhimurium specifically targets antigen-sampling microfold (M) cells to translocate across the gut epithelium. Although M cells represent a small proportion of the specialized follicular-associated epithelium (FAE) overlying mucosa-associated lymphoid tissues, their density increases during Salmonella infection, but the underlying molecular mechanism remains unclear. Using in vitro and in vivo infection models, we demonstrate that the S. Typhimurium type III effector protein SopB induces an epithelial-mesenchymal transition (EMT) of FAE enterocytes into M cells. This cellular transdifferentiation is a result of SopB-dependent activation of Wnt/β-catenin signaling leading to induction of both receptor activator of NF-κB ligand (RANKL) and its receptor RANK. The autocrine activation of RelB-expressing FAE enterocytes by RANKL/RANK induces the EMT-regulating transcription factor Slug that marks epithelial transdifferentiation into M cells. Thus, via the activity of a single secreted effector, S. Typhimurium transforms primed epithelial cells into M cells to promote host colonization and invasion. © 2012 Elsevier Inc.
Authors & Co-Authors
Tahoun, Amin Abd Elhady
Unknown Affiliation
Mahajan, Simmi
Unknown Affiliation
Paxton, Edith A.
Unknown Affiliation
Malterer, Georg
Unknown Affiliation
Donaldson, David S.
Unknown Affiliation
Wang, Dai
Unknown Affiliation
Tan, Alwyn
Unknown Affiliation
Gillespie, Trudi L.
Unknown Affiliation
O'Shea, Marie
Unknown Affiliation
Roe, Andrew J.
Unknown Affiliation
Shaw, Darren J.
Unknown Affiliation
Gally, David L.
Unknown Affiliation
Lengeling, Andreas
Unknown Affiliation
Mabbott, Neil Andrew
Unknown Affiliation
Haas, Jürgen G.
Unknown Affiliation
Mahajan, Arvind
Unknown Affiliation
Statistics
Citations: 160
Authors: 16
Affiliations: 6
Identifiers
Doi:
10.1016/j.chom.2012.10.009
ISSN:
19313128
e-ISSN:
19346069
Research Areas
Infectious Diseases