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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
The power of genetic diversity in genome-wide association studies of lipids
Nature, Volume 600, No. 7890, Year 2021
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Description
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels2, heart disease remains the leading cause of death worldwide3. Genome-wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS4–23 have been conducted in European ancestry populations and may have missed genetic variants that contribute to lipid-level variation in other ancestry groups. These include differences in allele frequencies, effect sizes and linkage-disequilibrium patterns24. Here we conduct a multi-ancestry, genome-wide genetic discovery meta-analysis of lipid levels in approximately 1.65 million individuals, including 350,000 of non-European ancestries. We quantify the gain in studying non-European ancestries and provide evidence to support the expansion of recruitment of additional ancestries, even with relatively small sample sizes. We find that increasing diversity rather than studying additional individuals of European ancestry results in substantial improvements in fine-mapping functional variants and portability of polygenic prediction (evaluated in approximately 295,000 individuals from 7 ancestry groupings). Modest gains in the number of discovered loci and ancestry-specific variants were also achieved. As GWAS expand emphasis beyond the identification of genes and fundamental biology towards the use of genetic variants for preventive and precision medicine25, we anticipate that increased diversity of participants will lead to more accurate and equitable26 application of polygenic scores in clinical practice. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
Authors & Co-Authors
Graham, Sarah E.
United States, Ann Arbor
University of Michigan, Ann Arbor
Clarke, Shoa L.
United States, Palo Alto
Va Palo Alto Health Care System
United States, Stanford
Stanford University School of Medicine
Wu, Kuan Han Hank
United States, Ann Arbor
University of Michigan, Ann Arbor
Kanoni, Stavroula
United Kingdom, London
Queen Mary University of London
Zajac, Gregory J.M.
United States, Ann Arbor
University of Michigan, Ann Arbor
Ramdas, Shweta
United States, Philadelphia
University of Pennsylvania
Surakka, Ida L.
United States, Ann Arbor
University of Michigan, Ann Arbor
Ntalla, Ioanna
United Kingdom, London
Queen Mary University of London
Vedantam, Sailaja
United States, Boston
Boston Children's Hospital
United States, Cambridge
Broad Institute
Winkler, Thomas W.
Germany, Regensburg
Universität Regensburg
Locke, Adam E.
United States, St. Louis
Washington University in St. Louis
Marouli, Eirini
United Kingdom, London
Queen Mary University of London
Hwang, Mi-yeong
South Korea, Cheongju
Korea National Institute of Health
Han, Sohee
South Korea, Cheongju
Korea National Institute of Health
Narita, Akira
Japan, Sendai
Tohoku University
Choudhury, Ananyo
South Africa, Johannesburg
University of the Witwatersrand
Bentley, Amy Rebecca
United States, Bethesda
National Institutes of Health Nih
Ekoru, Kenneth
United States, Bethesda
National Institutes of Health Nih
Verma, Anurag
United States, Philadelphia
University of Pennsylvania
Trivedi, Bhavi
United Kingdom, London
Queen Mary University of London
Martin, Hilary C.
United Kingdom, Hinxton
Wellcome Sanger Institute
Hunt, Karen A.
United Kingdom, London
Queen Mary University of London
Hui, Qin
United States, Atlanta
Emory University
United States, Decatur
Atlanta va Health Care System
Klarin, Derek M.
United States
Va Medical Center
United States, Gainesville
University of Florida College of Medicine
United States, Cambridge
Massachusetts Institute of Technology
Zhu, Xiang
United States, Palo Alto
Va Palo Alto Health Care System
United States, University Park
Pennsylvania State University
United States, Palo Alto
Stanford University
Thorleifsson, Gudmar
Iceland, Reykjavik
Decode Genetics
Helgadóttir, Anna
Iceland, Reykjavik
Decode Genetics
Gudbjartsson, Daníel Fannar
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Hólm, Hilma
Iceland, Reykjavik
Decode Genetics
Ólafsson, Ísleifur
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Akiyama, Masato
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Japan, Fukuoka
Kyushu University
Sakaue, Saori
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Japan, Suita
Graduate School of Medicine
Japan, Tokyo
The University of Tokyo
Terao, Chikashi C.
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Kanai, Masahiro
United States, Cambridge
Massachusetts Institute of Technology
Japan, Yokohama
Riken Center for Integrative Medical Sciences
United States, Boston
Harvard Medical School
Zhou, Wei
United States, Ann Arbor
University of Michigan, Ann Arbor
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Massachusetts Institute of Technology
Brumpton, Ben M.
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Norway, Trondheim
Universitetssykehuset I Trondheim
Rasheed, Humaira
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Ruotsalainen, Sanni E.
Finland, Helsinki
Helsingin Yliopisto
Havulinna, Aki Samuli
Finland, Helsinki
Helsingin Yliopisto
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Veturi, Yogasudha C.
United States, Philadelphia
University of Pennsylvania
Feng, Qiping
United States, Nashville
Vanderbilt University Medical Center
Rosenthal, Elisabeth A.
United States, Seattle
University of Washington
Lingren, Todd
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Pacheco, Jennifer A.
United States, Evanston
Northwestern University
Pendergrass, Sarah A.
United States, San Francisco
Genentech, Inc
Haessler, Jeffrey W.
United States, Seattle
Fred Hutchinson Cancer Center
Giulianini, Franco
United States, Boston
Brigham and Women's Hospital
Bradford, Yuki
United States, Philadelphia
University of Pennsylvania
Miller, Jason E.
United States, Philadelphia
University of Pennsylvania
Campbell, Archie I.
United Kingdom, Edinburgh
Western General Hospital
United Kingdom, Edinburgh
The University of Edinburgh
Lin, Kuang
United Kingdom, Oxford
University of Oxford
Millwood, Iona Y.
United Kingdom, Oxford
University of Oxford
Hindy, George
Qatar, Doha
Qatar University
Rasheed, Asif
Pakistan, Karachi
Center for Non-communicable Diseases
Faul, Jessica D.
United States, Ann Arbor
University of Michigan, Ann Arbor
Zhao, Wei
United States, Ann Arbor
University of Michigan, Ann Arbor
Weir, David R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Turman, Constance
United States, Boston
Harvard T.h. Chan School of Public Health
Huang, Hongyang
United States, Boston
Harvard T.h. Chan School of Public Health
Graff, Misa E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Mahajan, Anubha
United Kingdom, Oxford
University of Oxford
Brown, Michael R.
United States, San Francisco
Environmental Sciences Associates
Zhang, Weihua
United Kingdom, London
Imperial College London
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
United Kingdom, London
Imperial College Healthcare Nhs Trust
Yu, Ketian
United States, Ann Arbor
University of Michigan, Ann Arbor
Schmidt, Ellen M.
United States, Ann Arbor
University of Michigan, Ann Arbor
Pandit, Anita
United States, Ann Arbor
University of Michigan, Ann Arbor
Gustafsson, Stefan
Sweden, Solna
Science for Life Laboratory
Yin, Xianyong
United States, Ann Arbor
University of Michigan, Ann Arbor
Luan, Jian'fan N.An
United Kingdom, Cambridge
Mrc Epidemiology Unit
Zhao, Jinghua
United Kingdom, Cambridge
University of Cambridge
Matsuda, Fumihiko
Japan, Kyoto
Graduate School of Medicine
Jang, Hye-mi
South Korea, Cheongju
Korea National Institute of Health
Yoon, Kyungheon
South Korea, Cheongju
Korea National Institute of Health
Medina-Gõmez, Carolina
Netherlands, Rotterdam
Erasmus Mc
Pitsillides, Achilleas N.
United States, Boston
School of Public Health
Hottenga, Jouke Jan
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Amsterdam
Amsterdam Public Health
Willemsen, Gonneke A.H.M.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Amsterdam
Amsterdam Public Health
Wood, Andrew R.
United Kingdom, Exeter
University of Exeter
Ji, Yingji
United Kingdom, Exeter
University of Exeter
Gao, Zishan
China, Nanjing
Nanjing University of Traditional Chinese Medicine
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Haworth, S. J.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Bristol
University of Bristol
Mitchell, Ruth E.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Bristol
University of Bristol
Chai, Jinfang
Singapore, Singapore City
National University Health System
Aadahl, Mette
Denmark, Copenhagen
Frederiksberg Hospital
Yao, Jie
United States, Torrance
Harbor-ucla Medical Center
Manichaikul, Ani W.
United States, Charlottesville
University of Virginia
Warren, Helen R.
United Kingdom, London
Queen Mary University of London
Ramírez, Julia
United Kingdom, London
Queen Mary University of London
Bork-Jensen, Jette
Denmark, Copenhagen
Københavns Universitet
Kårhus, Line Lund
Denmark, Copenhagen
Frederiksberg Hospital
Goel, Anuj
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
John Radcliffe Hospital
Sabater-Lleal, Maria
Spain, Barcelona
Institut de Recerca Sant Pau ir Sant Pau
Sweden, Stockholm
Karolinska Institutet
Noordam, Raymond
Netherlands, Leiden
Leids Universitair Medisch Centrum
Sidore, Carlo
Italy, Rome
Consiglio Nazionale Delle Ricerche
Fiorillo, Edoardo
Italy, Monserrato
Cnr Istituto Di Ricerca Genetica e Biomedica
McDaid, Aaron F.
Switzerland, Lausanne
Université de Lausanne Unil
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Marqués-Vidal, Pedro Manuel
Switzerland, Lausanne
Université de Lausanne Unil
Wielscher, Matthias
United Kingdom, London
Mrc Centre for Environment and Health
Trompet, Stella
Netherlands, Leiden
Leids Universitair Medisch Centrum
Sattar, Naveed A.
United Kingdom, Glasgow
College of Medical, Veterinary & Life Sciences
Møllehave, Line Tang
Denmark, Copenhagen
Frederiksberg Hospital
Thuesen, Betina Heinsbæk
Denmark, Copenhagen
Frederiksberg Hospital
Munz, Matthias
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Germany, Berlin
Freie Universität Berlin
Germany, Berlin
Berliner Institut Für Gesundheitsforschung
Zeng, Lingyao
Germany, Munich
Technische Universität München
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Huang, Jianfeng
China, Beijing
Chinese Academy of Medical Sciences & Peking Union Medical College
Poveda, Alaitz
Sweden, Malmo
Lund University Diabetes Centre
Kurbasic, Azra
Sweden, Malmo
Lund University Diabetes Centre
Lamina, Claudia
Austria, Innsbruck
Medizinische Universitat Innsbruck
Forer, Lukas
Austria, Innsbruck
Medizinische Universitat Innsbruck
Scholz, Markus
Germany, Leipzig
Universität Leipzig
Galesloot, Tessel E.
Netherlands, Nijmegen
Radboud Universiteit
Bradfield, Jonathan P.
Unknown Affiliation
Daw, E. Warwick
United States, St. Louis
Washington University School of Medicine in St. Louis
Zmuda, Joseph M.
United States, Pittsburgh
University of Pittsburgh
Mitchell, Jonathan S.
Italy, Bolzano
Eurac Research
Fuchsberger, Christian
Italy, Bolzano
Eurac Research
Brody, Jennifer A.
United States, Seattle
University of Washington
Feitosa, Mary Furlan
United States, St. Louis
Washington University School of Medicine in St. Louis
Wojczynski, Mary K.
United States, St. Louis
Washington University School of Medicine in St. Louis
Preuss, Michael H.
United States, New York
Icahn School of Medicine at Mount Sinai
Mangino, Massimo
United Kingdom, London
King's College London
United Kingdom, London
Nihr Guy's and st Thomas' Biomedical Research Centre
Verweij, Niek
Netherlands, Groningen
Rijksuniversiteit Groningen
Engmann, Jorgen E.L.
United Kingdom, London
University College London
Kleber, Marcus Edi
Germany, Heidelberg
Universität Heidelberg
Germany, Munich
Synlab International Gmbh
Delgado, Graciela E.
Germany, Heidelberg
Universität Heidelberg
Huo, Shaofeng
China, Beijing
Chinese Academy of Sciences
Yang, Jian
Australia, Brisbane
The University of Queensland
China, Wenzhou
Wenzhou Medical University
Liu, Jun
United Kingdom, Oxford
University of Oxford
Leonard, Hampton L.
United States, Bethesda
National Institutes of Health Nih
United States, Glen Echo
Data Tecnica International
Marten, Jonathan
United Kingdom, Edinburgh
Western General Hospital
Schmidt, Börge
Germany, Duisburg
Universität Duisburg-essen
Cañadas Garre, Marisa
United Kingdom, Belfast
Queen's University Belfast
Nakatochi, Masahiro
Japan, Nagoya
Nagoya University Graduate School of Medicine
Wong, A. Kin On
United Kingdom, London
University College London
Hutri-Kähönen, Nina
Finland, Tampere
University Hospital of Tampere
Finland, Tampere
Tampere University
Sim, Xueling
Singapore, Singapore City
National University Health System
Xia, Rui
United States, Houston
University of Texas Health Science Center at Houston
Huerta-Chagoya, Alicia
Mexico, Mexico
Universidad Nacional Autónoma de México
Fernández, Juan Carlos
Mexico, Mexico
Instituto Nacional de Medicina Genómica
Lyssenko, Valeriya
Norway, Bergen
Universitetet I Bergen
Sweden, Lund
Lunds Universitet
Jackson, Anne U.
United States, Ann Arbor
University of Michigan, Ann Arbor
Irvin, Marguerite Ryan
United States, Birmingham
The University of Alabama at Birmingham
J Oldmeadow, Christopher
Australia, Newcastle
Hunter Medical Research Institute, Australia
Ryu, Seungho
South Korea, Suwon
Samsung Group
Timmers, Paul R.H.J.
United Kingdom, Edinburgh
Western General Hospital
United Kingdom, Edinburgh
The University of Edinburgh
Dorajoo, R. S.O.
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Lange, Leslie A.
United States, Aurora
University of Colorado Anschutz Medical Campus
Chai, Xiaoran
Singapore, Singapore City
Singapore National Eye Centre
Singapore, Singapore City
National University Health System
Prasad, Gauri
India, New Delhi
Council of Scientific and Industrial Research India
Pauper, M.
Netherlands, Nijmegen
Radboud University Medical Center
Long, Jirong
United States, Nashville
Vanderbilt University Medical Center
Li, Xiaohui
United States, Torrance
Harbor-ucla Medical Center
Takeuchi, Fumihiko
Japan, Tokyo
National Center for Global Health and Medicine
Spracklen, Cassandra N.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Amherst
University of Massachusetts Amherst
Loukola, Anu
Finland, Helsinki
Helsingin Yliopisto
Wang, Yaxing
China, Beijing
Beijing Institute of Ophthalmology
China, Beijing
Capital Medical University
Nutile, Teresa
Italy, Rome
Consiglio Nazionale Delle Ricerche
Ruggiero, Daniela
Italy, Rome
Consiglio Nazionale Delle Ricerche
Italy, Pozzilli
Istituto Neurologico Mediterraneo Neuromed, Pozzilli
Sung, Yunju
United States, St. Louis
Washington University in St. Louis
Hung, Yijen
Taiwan, Taipei
Triservice General Hospital Taiwan
Chen, Shufeng
China, Beijing
Chinese Academy of Medical Sciences & Peking Union Medical College
Yang, Jingyun
United States, Chicago
Rush University Medical Center
Kentistou, Katherine A.
United Kingdom, Edinburgh
The University of Edinburgh
Gorski, Mathias M.
Germany, Regensburg
Universität Regensburg
Germany, Regensburg
Klinikum Der Universität Regensburg Und Medizinische Fakultät
Brumat, Marco
Italy, Trieste
Università Degli Studi Di Trieste
Meidtner, Karina
Germany, Nuthetal
German Institute of Human Nutrition
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Bielak, Lawrence F.
United States, Ann Arbor
University of Michigan, Ann Arbor
Smith, Jennifer Anne
United States, Ann Arbor
University of Michigan, Ann Arbor
Hebbar, Prashantha
Kuwait, Dasman
Dasman Diabetes Institute
Hofer, Edith
Austria, Graz
Medizinische Universität Graz
Xue, Chao
United States, Ann Arbor
University of Michigan, Ann Arbor
Concas, Maria Pina
Italy, Trieste
Irccs Burlo Garofolo
van der Most, Peter J.
Netherlands, Groningen
Rijksuniversiteit Groningen
Cade, Brian E.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Lee, Jiwon
United States, Boston
Brigham and Women's Hospital
Chitrala, Kumaraswamy Naidu
United States, Bethesda
National Institutes of Health Nih
Weiss, Stefan
Germany, Greifswald
Universitätsmedizin Greifswald
Nethander, Maria
Sweden, Gothenburg
Göteborgs Universitet
Freitag-Wolf, Sandra
Germany, Kiel
Christian-albrechts-universität zu Kiel
Southam, Lorraine
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
United Kingdom, Hinxton
Wellcome Sanger Institute
Rayner, Nigel William
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Oxford
University of Oxford
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Wang, Carol A.
Australia, Callaghan
University of Newcastle, College of Health, Medicine and Wellbeing
Lyytikäinen, Leo Pekka
Finland, Tampere
Fimlab Laboratoriot oy
Finland, Tampere
Tampere University
Nikus, Kjell Christer
Finland, Tampere
University Hospital of Tampere
Finland, Tampere
Tampere University
Cuellar-Partida, Gabriel
Australia, Woolloongabba
Translational Research Institute Australia
Giannakopoulou, Olga
United Kingdom, London
Queen Mary University of London
van Setten, Jessica A.
Netherlands, Utrecht
Universiteit Utrecht
Schwander, Karen L.
United States, St. Louis
Washington University School of Medicine in St. Louis
Jackson, Rebecca D.
United States, Columbus
The Ohio State University
Reiner, Alexander Paul
United States, Seattle
University of Washington
Martin, Lisa Warsinger
United States, Washington, D.c.
The George Washington University
Chen, Zhengming
United Kingdom, Oxford
University of Oxford
Li, Liming
China, Beijing
Peking University Health Science Center
Highland, Heather M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Young, Kristin L.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Kawaguchi, Takahisa
Japan, Kyoto
Graduate School of Medicine
Thiery, Joachim
Germany, Leipzig
Universität Leipzig
Germany, Leipzig
Universitätsklinikum Leipzig Und Medizinische Fakultät
Bis, Joshua C.M.
United States, Seattle
University of Washington
Nadkarni, Girish N.
United States, New York
Icahn School of Medicine at Mount Sinai
Launer, Lenore J.
United States, Bethesda
National Institutes of Health Nih
Nalls, Mike A.
United States, Bethesda
National Institutes of Health Nih
United States, Glen Echo
Data Tecnica International
Raitakari, Olli T.
Finland, Turku
Turun Yliopisto
Finland, Turku
Turun Yliopistollinen Keskussairaala
Ichihara, Sahoko
Japan, Kawachi District
Jichi Medical University
Nelson, Christopher P.
United Kingdom, Leicester
University of Leicester
Campbell, Harry
United Kingdom, Edinburgh
The University of Edinburgh
Nabika, Tohru
Japan, Izumo
Shimane University Faculty of Medicine
Al-Mulla, F.
Kuwait, Dasman
Dasman Diabetes Institute
Niinikoski, Harri
Finland, Turku
Turun Yliopisto
Braund, Peter S.
United Kingdom, Leicester
University of Leicester
Kolcic, Ivana
Croatia, Split
University of Split
Kovács, Péter F.
Germany, Leipzig
Universität Leipzig
Bhatti, Konain Fatima
United Kingdom, London
Queen Mary University of London
de Borst, Gert Jan
Netherlands, Utrecht
Universiteit Utrecht
Adams, Hieab H.H.
Netherlands, Rotterdam
Erasmus Mc
Ikram, Mohammad Arfan
Netherlands, Rotterdam
Erasmus Mc
Asselbergs, Folkert W.
Netherlands, Utrecht
Universiteit Utrecht
Kraaijeveld, Adriaan O.
Netherlands, Utrecht
Universiteit Utrecht
Beulens, J. W.J.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Utrecht
University Medical Center Utrecht
Shu, Xiaoou
United States, Nashville
Vanderbilt University Medical Center
Rallidis, Lοukianos S.
Greece, Athens
Attikon University Hospital
Pedersen, Oluf Borbye
Denmark, Copenhagen
Københavns Universitet
Hansen, Torben Frøstrup
Denmark, Copenhagen
Københavns Universitet
Mitchell, Paul A.
Australia, Sydney
The University of Sydney
Kähönen, Mika A.P.
Finland, Tampere
University Hospital of Tampere
Finland, Tampere
Tampere University
Bouchard, Claude E.
United States, Baton Rouge
Pennington Biomedical Research Center
Tönjes, Anke
Germany, Leipzig
Universität Leipzig
Chen, Yii Der Ida
United States, Torrance
Harbor-ucla Medical Center
Pennell, Craig Edward
Australia, Callaghan
University of Newcastle, College of Health, Medicine and Wellbeing
Mori, Trevor A.
Australia, Perth
The University of Western Australia
Lieb, Wolfgang
Germany, Kiel
Christian-albrechts-universität zu Kiel
Franke, Andre
Germany, Kiel
Christian-albrechts-universität zu Kiel
Ohlsson, Claes
Sweden, Gothenburg
Göteborgs Universitet
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Cho, Yoon-shin
South Korea, Chuncheon
Hallym University
Yuan, Jianmin
United States, Pittsburgh
University of Pittsburgh
Koh, Woon Puay
Singapore, Singapore City
National University of Singapore
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Heid, Iris Maria
Germany, Regensburg
Universität Regensburg
Völzke, Henry
Germany, Greifswald
Universitätsmedizin Greifswald
Homuth, Georg
Germany, Greifswald
Universitätsmedizin Greifswald
Evans, Michele Kim
United States, Bethesda
National Institutes of Health Nih
Zonderman, Alan B.
United States, Bethesda
National Institutes of Health Nih
Polašek, Ozren
Croatia, Split
University of Split
Redline, Susan S.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Oldehinkel, Albertine J.(Tineke)
Netherlands, Groningen
Rijksuniversiteit Groningen
Snieder, Harold
Netherlands, Groningen
Rijksuniversiteit Groningen
Biino, Ginevra
Italy, Rome
Consiglio Nazionale Delle Ricerche
Schmidt, Reinhold T.
Austria, Graz
Medizinische Universität Graz
Schmidt, Helena
Austria, Graz
Medizinische Universität Graz
Bandinelli, Stefania S.
Unknown Affiliation
Dedoussis, George V.Z.
Greece, Athens
Harokopio University of Athens
Thanaraj, Thangavel Alphonse
Kuwait, Dasman
Dasman Diabetes Institute
Kardia, Sharon L.R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Kato, Norihiro
Japan, Tokyo
National Center for Global Health and Medicine
Schulze, Matthias Bernd
Germany, Nuthetal
German Institute of Human Nutrition
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Potsdam
Universität Potsdam
Girotto, Giorgia G.
Italy, Trieste
Università Degli Studi Di Trieste
Italy, Trieste
Irccs Burlo Garofolo
Jung, Bettina
Germany, Regensburg
Klinikum Der Universität Regensburg Und Medizinische Fakultät
Böger, Carsten Alexander
Germany, Regensburg
Klinikum Der Universität Regensburg Und Medizinische Fakultät
Germany, Traunstein
Hospital Traunstein
Joshi, Peter K.
United Kingdom, Edinburgh
The University of Edinburgh
Bennett, David Alan
United States, Chicago
Rush University Medical Center
de Jager, Philip Lawrence
United States, New York
Columbia University Irving Medical Center
United States, Cambridge
Broad Institute
Lu, Xiangfeng
China, Beijing
Chinese Academy of Medical Sciences & Peking Union Medical College
Mamakou, Vasiliki
Greece, Athens
National and Kapodistrian University of Athens
Greece, Athens
Dromokaiteio Psychiatric Hospital
Brown, Morris J.
United Kingdom, London
Queen Mary University of London
Caulfield, Mark J.
United Kingdom, London
Queen Mary University of London
Munroe, Patricia B.
United Kingdom, London
Queen Mary University of London
Guo, Xiuqing
United States, Torrance
Harbor-ucla Medical Center
Jonas, Jost Bruno
Germany, Heidelberg
Universität Heidelberg
China, Beijing
Capital Medical University
Switzerland, Basel
Institute of Molecular and Clinical Ophthalmology Basel
Samani, Nilesh J.
United Kingdom, Leicester
University of Leicester
Kaprio, Jaakko A.
Finland, Helsinki
Helsingin Yliopisto
Pajukanta, Päivi E.
United States, Los Angeles
University of California, Los Angeles
Adair, Linda S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Bechayda, Sonny A.
Philippines, Cebu
University of San Carlos
de Silva, Hithanadura Janaka
Sri Lanka, Kelaniya
University of Kelaniya
Wickramasinghe, Ananda Rajitha
Sri Lanka, Kelaniya
University of Kelaniya
Krauss, Ronald M.
United States, San Francisco
University of California, San Francisco
Wu, Jeryuarn
Taiwan, Nankang
Academia Sinica Taiwan
Zheng, Wei
United States, Nashville
Vanderbilt University Medical Center
Den Hollander, Anneke I.
Netherlands, Nijmegen
Radboud University Medical Center
Bharadwaj, Dwaipayan
India, New Delhi
Council of Scientific and Industrial Research India
India, New Delhi
Jawaharlal Nehru University
Correa, Adolfo
United States, Jackson
University of Mississippi Medical Center
Wilson, James Gaines
United States, Jackson
University of Mississippi Medical Center
Lind, Lars L.
Sweden, Uppsala
Uppsala Universitet
Golightly, Yvonne M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Wilson, James F.
United Kingdom, Edinburgh
Western General Hospital
United Kingdom, Edinburgh
The University of Edinburgh
Penninx, Brenda W. J. H.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Amsterdam
Amsterdam Public Health
Attia, John Richard
Australia, Newcastle
Hunter Medical Research Institute, Australia
Australia, Callaghan
The University of Newcastle, Australia
Scott, Rodney J.
Australia, Newcastle
Hunter Medical Research Institute, Australia
Australia, Callaghan
The University of Newcastle, Australia
Rao, Dabeeru C.
United States, St. Louis
Washington University School of Medicine in St. Louis
Arnett, Donna K.
United States, Lexington
University of Kentucky
Walker, Mark A.
United Kingdom, Newcastle
Newcastle University
Koistinen, Heikki A.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Finland, Helsinki
Helsinki University Hospital
Finland, Helsinki
Minerva Foundation Institute for Medical Research Helsinki
Ratan Chandak, Giriraj Ratan
India, Hyderabad
Centre for Cellular and Molecular Biology India
India, Ghaziabad
Academy of Scientific and Innovative Research Acsir
Yajnik, Chittaranjan Sakerlal
India, Pune
Kem Hospital
Mercader, Josep Maria
United States, Boston
Harvard Medical School
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
Aguilar Salinas, Carlos A.
Mexico, Tlalpan
Instituto Nacional de la Nutrición Salvador Zubiran
Villalpando, Clicerio González
Mexico, Cuernavaca
Instituto Nacional de Salud Publica
Orozco, Lorena S.
Mexico, Mexico
Instituto Nacional de Medicina Genómica
Fornage, Myriam
United States, Houston
University of Texas Health Science Center at Houston
Tai, E. Shyong
Singapore, Singapore City
National University Health System
van Dam, Robertus Martinus
Singapore, Singapore City
National University Health System
Lehtimäki, Terho J.
Finland, Tampere
Fimlab Laboratoriot oy
Finland, Tampere
Tampere University
Chaturvedi, Nish R.
United Kingdom, London
University College London
Liu, Jianjun
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Reilly, Dermot F.
United States, Rahway
Merck & Co., Inc.
McKnight, Amy Jayne
United Kingdom, Belfast
Queen's University Belfast
Kee, Frank
United Kingdom, Belfast
Queen's University Belfast
Jöckel, Karl Heinz
Germany, Duisburg
Universität Duisburg-essen
McCarthy, Mark I.
United States, San Francisco
Genentech, Inc
United Kingdom, Oxford
University of Oxford
Palmer, Colin Neil Alexander
United Kingdom, Dundee
University of Dundee
Vitart, Véronique
United Kingdom, Edinburgh
Western General Hospital
Hayward, Caroline
United Kingdom, Edinburgh
Western General Hospital
van Duijn, Cornelia M.
United Kingdom, Oxford
University of Oxford
Mar̈z, Winfried
Germany, Heidelberg
Universität Heidelberg
Germany, Munich
Synlab International Gmbh
Austria, Graz
Medizinische Universität Graz
Parra, Esteban J.
Canada, Toronto
University of Toronto
Gudnason, V. G.
Iceland, Kopavogur
Icelandic Heart Association
Iceland, Reykjavik
Haskoli Islands
Tardif, Jean Claude
Canada, Montreal
Institut de Cardiologie de Montreal
Canada, Montreal
University of Montreal
Lettre, Guillaume
Canada, Montreal
Institut de Cardiologie de Montreal
Canada, Montreal
University of Montreal
Damrauer, Scott M.
United States, Philadelphia
University of Pennsylvania
United States
Va Medical Center
Kumari, Meena
United Kingdom, Colchester
University of Essex
Kivimaki, Mika Shipley
United Kingdom, London
University College London
van der Harst, Pim
Netherlands, Groningen
Rijksuniversiteit Groningen
Spector, Tim David
United Kingdom, London
King's College London
Loos, Ruth J.F.
United States, New York
Icahn School of Medicine at Mount Sinai
Province, Michael A.
United States, St. Louis
Washington University School of Medicine in St. Louis
Psaty, Bruce M.
United States, Seattle
University of Washington
Brandslund, Ivan
Denmark, Vejle
Sygehus Lillebælt - Vejle
Denmark, Odense
Syddansk Universitet
Pramstaller, Peter P.
Italy, Bolzano
Eurac Research
Christensen, Kaare
Denmark, Odense
Syddansk Universitet
Ripatti, Samuli O.
Finland, Helsinki
Helsingin Yliopisto
United States, Cambridge
Massachusetts Institute of Technology
Widén, Elisabeth E.
Finland, Helsinki
Helsingin Yliopisto
Håkonarson, Håkon H.
United States, Philadelphia
The Children's Hospital of Philadelphia
United States, Philadelphia
University of Pennsylvania
Grant, Struan F.A.
United States, Philadelphia
University of Pennsylvania
United States, Philadelphia
The Children's Hospital of Philadelphia
Kiemeney, Lambertus A.L.M.
Netherlands, Nijmegen
Radboud Universiteit
de Graaf, Jacqueline J.
Netherlands, Nijmegen
Radboud Universiteit
Loeffler, Markus
Germany, Leipzig
Universität Leipzig
Kronenberg, Florian
Austria, Innsbruck
Medizinische Universitat Innsbruck
Erdmann, Jeanette
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Schunkert, Heribert
Germany, Munich
Technische Universität München
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Franks, Paul W.
Sweden, Malmo
Lund University Diabetes Centre
Linneberg, Allan R.
Denmark, Copenhagen
Frederiksberg Hospital
Denmark, Copenhagen
Københavns Universitet
Jukema, Johan Wouter
Netherlands, Leiden
Leids Universitair Medisch Centrum
Netherlands, Utrecht
Netherlands Heart Institute
Khera, Amit Vikram
United States, Boston
Massachusetts General Hospital
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Männikkö, Minna
Finland, Oulu
Oulun Yliopisto
J̈arvelin, Märjo Riitta R.
United Kingdom, London
Mrc Centre for Environment and Health
Finland, Oulu
Oulun Yliopisto
Kutalik, Zoltán
Switzerland, Lausanne
Sib Swiss Institute of Bioinformatics
Cucca, Francesco
Italy, Rome
Consiglio Nazionale Delle Ricerche
Italy, Sassari
Università Degli Studi Di Sassari
Mook-Kanamori, Dennis Owen
Netherlands, Leiden
Leids Universitair Medisch Centrum
van Dijk, Ko Willems
Netherlands, Leiden
Leids Universitair Medisch Centrum
Watkins, Hugh C.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
John Radcliffe Hospital
Strachan, David P.
United Kingdom, London
St George’s, University of London
Grarup, Niels
Denmark, Copenhagen
Københavns Universitet
Sever, Peter S.
United Kingdom, London
Imperial College London
Poulter, Neil R.
United Kingdom, London
Imperial College London
Rotter, Jerome I.
United States, Torrance
Harbor-ucla Medical Center
Karpe, Fredrik
United Kingdom, Oxford
Churchill Hospital
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Neville, Matt J.
United Kingdom, Oxford
Churchill Hospital
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Timpson, Nicholas J.
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
United Kingdom, Bristol
University of Bristol
Wong, Tienyin
Singapore, Singapore City
Singapore National Eye Centre
Singapore, Singapore City
Duke-nus Medical School
Khor, Chiea Chuen
Singapore, Singapore City
Agency for Science, Technology and Research, Singapore
Peters, Annette Michael
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Germany, Berlin
Deutsches Zentrum Für Herz-kreislauf-forschung E. V.
Gieger, Christian
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Oberschleissheim
Deutsches Zentrum Für Diabetesforschung
Hattersley, Andrew T.
United Kingdom, Exeter
University of Exeter
Pedersen, Nancy Lee
Sweden, Stockholm
Karolinska Institutet
Magnusson, Patrik K.E.
Sweden, Stockholm
Karolinska Institutet
Boomsma, Dorret I.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Amsterdam
Amsterdam Public Health
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
de Geus, Eco J.C.N.
Netherlands, Amsterdam
Vrije Universiteit Amsterdam
Netherlands, Amsterdam
Amsterdam Public Health
Cupples, Laura Adrienne
United States, Boston
School of Public Health
United States, Bethesda
National Institutes of Health Nih
Van Meurs, Joyce B.J.
Netherlands, Rotterdam
Erasmus Mc
Ghanbari, Mohsen
Netherlands, Rotterdam
Erasmus Mc
Iran, Mashhad
Mashhad University of Medical Sciences
Kim, Young Jin
South Korea, Cheongju
Korea National Institute of Health
Wareham, Nicholas J.
United Kingdom, Cambridge
Mrc Epidemiology Unit
Langenberg, Claudia C.
United Kingdom, Cambridge
Mrc Epidemiology Unit
Zeggini, Eleftheria
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
United Kingdom, Hinxton
Wellcome Sanger Institute
Germany, Munich
Technische Universität München
Kuusisto, Johanna K.
Finland, Kuopio
Kuopio University Hospital
Ingelsson, Erik
United States, Stanford
Stanford University School of Medicine
Sweden, Solna
Science for Life Laboratory
United States, Palo Alto
Stanford University
Abecasis, Gonçalo R.
United States, Ann Arbor
University of Michigan, Ann Arbor
United States, Tarrytown
Regeneron Pharmaceuticals, Inc.
Chambers, John Campbell
United Kingdom, London
Imperial College London
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
Singapore, Singapore City
Lee Kong Chian School of Medicine
Kooner, Jaspal Singh
United Kingdom, Harrow
London North West University Healthcare Nhs Trust
United Kingdom, London
Imperial College Healthcare Nhs Trust
United Kingdom, London
Mrc Centre for Environment and Health
United Kingdom, London
Imperial College London
de Vries, Paul S.
United States, San Francisco
Environmental Sciences Associates
Morrison, Alanna C.
United States, San Francisco
Environmental Sciences Associates
North, Kari E.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Kraft, Peter
United States, Boston
Harvard T.h. Chan School of Public Health
Martin, Nicholas G.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Whitfield, John B.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Saleheen, Danish
Pakistan, Karachi
Center for Non-communicable Diseases
United States, New York
Columbia University Irving Medical Center
Holmes, Michael V.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Nihr Oxford Biomedical Research Centre
Smith, Blair H.
United Kingdom, Dundee
University of Dundee
Justice, Anne E.
United States, Danville
Geisinger
Baras, Aris
United States, Tarrytown
Regeneron Pharmaceuticals, Inc.
Buring, Julie E.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Ridker, Paul M.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Chasman, Daniel I.
United States, Boston
Brigham and Women's Hospital
United States, Boston
Harvard Medical School
Kooperberg, Charles L.
United States, Seattle
Fred Hutchinson Cancer Center
Wei, Weiqi
United States, Nashville
Vanderbilt University Medical Center
Jarvik, Gail P.
United States, Seattle
Uw Medical Center – Montlake
Namjou, Bahram
United States, Cincinnati
Cincinnati Children's Hospital Medical Center
Hayes, Matthew Geoffrey
United States, Evanston
Northwestern University
Ritchie, Marylyn D.
United States, Philadelphia
University of Pennsylvania
Jousilahti, Pekka J.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Salomaa, Veikko V.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Hveem, Kristian
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
Åsvold, Bjørn Olav
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
Norway, Trondheim
Universitetssykehuset I Trondheim
Kubo, Michiaki
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Kamatani, Yoichiro
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Japan, Tokyo
The University of Tokyo
Okada, Yukinori
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Japan, Suita
Graduate School of Medicine
Japan, Suita
Osaka University
Murakami, Yoshinori S.
Japan, Tokyo
The University of Tokyo
Thorsteinsdóttir, Unnur Arna
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Stefánsson, Kari
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Ho, Yuklam
United States, West Roxbury
Va Boston Healthcare System
Rader, Daniel J.
United States, Philadelphia
University of Pennsylvania
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
Tsao, Phillip Shih Chung
United States, Palo Alto
Va Palo Alto Health Care System
United States, Stanford
Stanford University School of Medicine
Chang, Kyongmi
United States, Philadelphia
University of Pennsylvania Perelman School of Medicine
United States
Va Medical Center
Cho, Kelly M.
United States, West Roxbury
Va Boston Healthcare System
United States, Boston
Brigham and Women's Hospital
O′Donnell, Christopher J.
United States, West Roxbury
Va Boston Healthcare System
United States, Boston
Brigham and Women's Hospital
Gaziano, John Michael
United States, West Roxbury
Va Boston Healthcare System
United States, Boston
Brigham and Women's Hospital
Wilson, Peter W.F.
United States, Decatur
Atlanta va Medical Center
United States, Atlanta
Emory University School of Medicine
Rotimi, Charles N.
United States, Bethesda
National Institutes of Health Nih
Hazelhurst, Scott
South Africa, Johannesburg
University of the Witwatersrand
Ramsay, Michèle
South Africa, Johannesburg
University of the Witwatersrand
Trembath, Richard C.
United Kingdom, London
King's College London
van Heel, David A.
United Kingdom, London
Queen Mary University of London
Yamamoto, Masayuki
Japan, Sendai
Tohoku University
Kim, Bongjo
South Korea, Cheongju
Korea National Institute of Health
Mohlke, Karen
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Frayling, Tim M.
United Kingdom, Exeter
University of Exeter
Hirschhorn, Joel N.
United States, Boston
Boston Children's Hospital
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Kathiresan, Sekar
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Boehnke, Michael L.
United States, Ann Arbor
University of Michigan, Ann Arbor
Natarajan, Pradeep
United States, Cambridge
Massachusetts Institute of Technology
United States, Boston
Massachusetts General Hospital
Peloso, Gina Marie
United States, Boston
School of Public Health
Brown, Christopher D.
United States, Philadelphia
University of Pennsylvania
Morris, Andrew Paul
United Kingdom, Manchester
The University of Manchester
Assimes, Themistocles L.
United States, Palo Alto
Va Palo Alto Health Care System
United States, Stanford
Stanford University School of Medicine
Deloukas, Panos
United Kingdom, London
Queen Mary University of London
Saudi Arabia, Jeddah
King Abdulaziz University
Sun, Yan V.
United States, Atlanta
Emory University
United States, Decatur
Atlanta va Health Care System
Willer, Cristen J.
United States, Ann Arbor
University of Michigan, Ann Arbor
Saudi Arabia, Jeddah
King Abdulaziz University
Statistics
Citations: 306
Authors: 435
Affiliations: 242
Identifiers
Doi:
10.1038/s41586-021-04064-3
ISSN:
00280836
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Systematic review