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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
veterinary
Camel Streptococcus agalactiae populations are associated with specific disease complexes and acquired the tetracycline resistance gene tetM via a Tn916-like element
Veterinary Research, Volume 44, No. 1, Article 86, Year 2013
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Description
Camels are the most valuable livestock species in the Horn of Africa and play a pivotal role in the nutritional sustainability for millions of people. Their health status is therefore of utmost importance for the people living in this region. Streptococcus agalactiae, a Group B Streptococcus (GBS), is an important camel pathogen. Here we present the first epidemiological study based on genetic and phenotypic data from African camel derived GBS. Ninety-two GBS were characterized using multilocus sequence typing (MLST), capsular polysaccharide typing and in vitro antimicrobial susceptibility testing. We analysed the GBS using Bayesian linkage, phylogenetic and minimum spanning tree analyses and compared them with human GBS from East Africa in order to investigate the level of genetic exchange between GBS populations in the region. Camel GBS sequence types (STs) were distinct from other STs reported so far. We mapped specific STs and capsular types to major disease complexes caused by GBS. Widespread resistance (34%) to tetracycline was associated with acquisition of the tetM gene that is carried on a Tn916-like element, and observed primarily among GBS isolated from mastitis. The presence of tetM within different MLST clades suggests acquisition on multiple occasions. Wound infections and mastitis in camels associated with GBS are widespread and should ideally be treated with antimicrobials other than tetracycline in East Africa. © 2013 Fischer et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3850529/bin/1297-9716-44-86-S1.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3850529/bin/1297-9716-44-86-S2.xlsx
Authors & Co-Authors
Fischer, Anne H.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Kenya, Nairobi
International Centre of Insect Physiology and Ecology Nairobi
Liljander, Anne Mariana
Kenya, Nairobi
International Livestock Research Institute Nairobi
Kaspar, Heike
Germany, Berlin
Federal Office of Consumer Protection and Food Safety Bvl
Muriuki, Cecilia W.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Fuxelius, H. H.
Sweden, Uppsala
Sveriges Lantbruksuniversitet
Bongcàm-Rudloff, Erik
Sweden, Uppsala
Sveriges Lantbruksuniversitet
De Villiers, Etienne P.
United Kingdom, Oxford
University of Oxford
Huber, Charlotte A.
Unknown Affiliation
Frey, Joachim
Switzerland, Bern
University of Bern
Daubenberger, Claudia Andrea
Unknown Affiliation
Bishop, Richard Peter
Kenya, Nairobi
International Livestock Research Institute Nairobi
Younan, Mario
Unknown Affiliation
Jores, Joerg
Kenya, Nairobi
International Livestock Research Institute Nairobi
Statistics
Citations: 39
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1186/1297-9716-44-86
ISSN:
09284249
e-ISSN:
12979716
Research Areas
Genetics And Genomics
Study Locations
Multi-countries