Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets
Virology, Volume 422, No. 1, Year 2012
Notification
URL copied to clipboard!
Description
Several early pandemic H1N1 influenza isolates cause severe disease in different animals models, while most strains result in mild clinical signs similar to seasonal influenza. In this study, the pathogenesis of the virulent Mexican isolate A/Mexico/InDRE4487/2009 and a mild Canadian isolate A/Canada-AB/RV1532/2009 was compared in ferrets. These viruses differed at nine residues, none of which has been previously identified as virulence factor. The Mexican isolate caused more severe disease and higher mortality, and reached higher peak nasal wash titers. Both viruses grew similarly in the respiratory tract, but only the virulent virus was detected in the gut after day 3. During the acute phase, both strains caused similar lung pathology, however the Mexican isolate induced severe inflammation even after virus clearance. This virus was also associated with a rapid and sustained induction of inflammatory cytokines, indicating that early dysregulation of the host response contributes importantly to the disease outcome. © 2011 Elsevier Inc.
Authors & Co-Authors
Embury-Hyatt, Carissa K.
Canada, Ottawa
Canadian Food Inspection Agency Cfia
Gray, Michael J.
Canada, Ottawa
Public Health Agency of Canada
Bastien, Nathalie
Canada, Ottawa
Public Health Agency of Canada
Li, Yan
Canada, Ottawa
Public Health Agency of Canada
Plummer, Francis Allan
Canada, Ottawa
Public Health Agency of Canada
Canada, Winnipeg
University of Manitoba
Kobinger, Gary P.
Canada, Ottawa
Public Health Agency of Canada
Canada, Winnipeg
University of Manitoba
Von Messling, Veronika Al
Canada, Laval
Centre Armand-frappier Santé Biotechnologie
Singapore, Singapore City
Duke-nus Medical School
Statistics
Citations: 37
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1016/j.virol.2011.10.018
ISSN:
10960341