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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Coexistence of urogenital schistosomiasis and sexually transmitted infection in women and men living in an area where Schistosoma haematobium is endemic
Clinical Infectious Diseases, Volume 47, No. 6, Year 2008
Notification
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Description
Background. In settings in which adequate laboratory service is lacking, the coexistence of urogenital schistosomiasis and sexually transmitted infections (STIs) poses a diagnostic challenge for health care providers in the management of patients with urogenital complaints. Methods. Symptoms were recorded with use of a semistructured questionnaire at baseline and in follow-up surveys after STI and Schistosoma haematobium infection had been assessed and systematically treated as part of a community-based study of 253 women and 236 men, aged 15-49 years, living in an area of Madagascar where S. haematobium is endemic. Results. Of those infected with S. haematobium, 35% of the women had concordant STI (e.g., infection with Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, and/or Trichomonas vaginalis), compared with 17% of the men. Both S. haematobium infection and STI were significantly more common among younger individuals, aged 15-24 years, than among older individuals. A broad spectrum of urogenital symptoms was reported. However, one-half of the women and men who had positive test results for an STI or for S. haematobium infection were asymptomatic. Gross hematuria and dysuria were, in multivariate analysis, associated with S. haematobium infection, as were genitopelvic discomfort in women and ejaculation pain in men. The association became stronger with higher intensity of infection. In bivariate analysis but not in the multiregression model, STI was associated with vaginal discharge and genitopelvic discomfort in women and was associated with urethral discharge in men. Conclusions. The rationale for empirical antischistosoma treatment of adolescents and younger adults in areas where S. haematobium is endemic, with praziquantel alone or in combination with existing anti-STI regimens, is discussed. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Leutscher, Peter Derek Christian
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Denmark, Copenhagen
Dbl -center for Health Research and Development
Ramarokoto, Charles Emile
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Hoffmann, Steen
Denmark, Copenhagen
Statens Serum Institut
Jensen, Jörgen Skov
Denmark, Copenhagen
Statens Serum Institut
Ramaniraka, V.
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Randrianasolo, Bodo Sahondra
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Raharisolo, Clairette V.
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Migliani, René
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Christensen, Niels Örnbjerg
Denmark, Copenhagen
Dbl -center for Health Research and Development
Statistics
Citations: 56
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1086/591127
ISSN:
10584838
Research Areas
Infectious Diseases
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Madagascar
Participants Gender
Male
Female