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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
DNA 'barcoding' of Schistosoma mansoni across sub-Saharan Africa supports substantial within locality diversity and geographical separation of genotypes
Acta Tropica, Volume 128, No. 2, Year 2013
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Description
Schistosoma mansoni is a widespread human helminth and causes intestinal schistosomiasis in 54 countries, mainly across Africa but also in Madagascar, the Arabian Peninsula and the neotropics. The geographical range of this parasite relies on the distribution of certain species of freshwater pulmonate snails of the genus Biomphalaria. Whilst S. mansoni is known to exhibit high population diversity the true extent of this diversity is still to be fully elucidated as sampling of this taxon progressively accrues. Here a DNA 'barcoding' approach is taken using sequence analysis of a 450. bp region within the mitochondrial cox1 gene to assess the genetic diversity within a large number of S. mansoni larval stages collected from their natural human hosts across sub-Saharan Africa. Five hundred and sixty one individual parasite samples were examined from 22 localities and 14 countries. Considerable within-species diversity was found with 120 unique haplotypes splitting geographically into five discrete lineages. The highest diversity was found in East Africa with samples forming three of the five lineages. Less diversity was found in the Far and Central Western regions of Africa with haplotypes from the New World showing a close affinity to the Far Western African S. mansoni populations supporting the hypothesis of a colonisation of South America via the West African slave trade. The data are discussed in relation to parasite diversity and disease epidemiology. © 2012 Elsevier B.V.
Authors & Co-Authors
Webster, Bonnie L.
United Kingdom, London
The Natural History Museum, London
Webster, Joanne P.
United Kingdom, London
Imperial College London
Gouvras, Anouk N.
United Kingdom, London
The Natural History Museum, London
Garba, A. Djirmay
Unknown Affiliation
Lamine, Mariama Sani
Unknown Affiliation
Diaw, Omar Talla
Senegal, Dakar
Institut Sénégalais de Recherches Agricoles Dakar
Seye, Mouhamadane
Senegal, Dakar
Institut Sénégalais de Recherches Agricoles Dakar
Tchuem Tchuenté, Louis Albert
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Yaounde
Center for Schistosomiasis and Parasitology
Simoonga, Christopher
Zambia, Lusaka
University of Zambia
Mubila, Likezo
Zambia, Lusaka
University of Zambia
Mwanga, Joseph Rogathe
Tanzania, Tanga
National Institute for Medical Research Tanga
Lwambo, Nicholas J.S.
Tanzania, Tanga
National Institute for Medical Research Tanga
Kabatereine, Narcis B.
Uganda, Kampala
Uganda Ministry of Health
Lange, Charles N.
Kenya, Nairobi
National Museums of Kenya
Kariuki, Curtis H.
Kenya, Nairobi
National Museums of Kenya
Mkoji, Gerald M.
Kenya, Nairobi
Kenya Medical Research Institute
Rollinson, D.
United Kingdom, London
The Natural History Museum, London
Russell Stothard, John Russell
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Statistics
Citations: 29
Authors: 18
Affiliations: 11
Identifiers
Doi:
10.1016/j.actatropica.2012.08.009
ISSN:
0001706X
e-ISSN:
18736254
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Madagascar