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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HIV-1 drug resistance in recently HIV-infected pregnant mother's naïve to antiretroviral therapy in Dodoma urban, Tanzania
BMC Infectious Diseases, Volume 13, No. 1, Article 439, Year 2013
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Description
Background: HIV resistance affects virological response to therapy and efficacy of prophylaxis in mother-to-child-transmission. The study aims to assess the prevalence of HIV primary resistance in pregnant women naïve to antiretrovirals.Methods: Cross sectional baseline analysis of a cohort of HIV + pregnant women (HPW) enrolled in the study entitled Antiretroviral Management of Antenatal and Natal HIV Infection (AMANI, peace in Kiswahili language). The AMANI study began in May 2010 in Dodoma, Tanzania. In this observational cohort, antiretroviral treatment was provided to all women from the 28th week of gestation until the end of the breastfeeding period. Baseline CD4 cell count, viral load and HIV drug-resistance genotype were collected.Results: Drug-resistance analysis was performed on 97 naïve infected-mothers. The prevalence of all primary drug resistance and primary non-nucleoside reverse-transcriptase inhibitors resistance was 11.9% and 7.5%, respectively. K103S was found in two women with no M184V detection. HIV-1 subtype A was the most commonly identified, with a high prevalence of subtype A1, followed by C, D, C/D recombinant, A/C recombinant and A/D recombinant. HIV drug- resistance mutations were detected in A1 and C subtypes.Conclusion: Our study reports an 11.9% prevalence rate of primary drug resistance in naïve HIV-infected pregnant women from a remote area of Tanzania. Considering that the non-nucleoside reverse-transcriptase inhibitors are part of the first-line antiretroviral regimen in Tanzania and all of Africa, resistance surveys should be prioritized in settings where antiretroviral therapy programs are scaled up. © 2013 Vairo et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Vairo, Francesco
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Nicastri, Emanuele
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Liuzzi, Giuseppina
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Chaula, Zainab
Tanzania
Dodoma Regional Hospital
Nguhuni, Boniface
Tanzania
Dodoma Regional Hospital
Bevilacqua, Nazario
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Forbici, Federica
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Amendola, Alessandra
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Fabeni, Lavinia
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
De Nardo, Pasquale
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Perno, Carlo Federico
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Cannas, Angela
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Sakhoo, Calistus
Tanzania
Dodoma Regional Hospital
Capobianchi, Maria Rosaria
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Ippolito, Giuseppe
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Statistics
Citations: 20
Authors: 15
Affiliations: 2
Identifiers
Doi:
10.1186/1471-2334-13-439
e-ISSN:
14712334
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Tanzania
Participants Gender
Female