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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Immunogenetic Control of Antibody Responsiveness in a Malaria Endemic Area
Human Immunology, Volume 68, No. 3, Year 2007
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Description
This study builds upon the established genetic control of antimalarial immune responses and prior association studies by using a family-based approach, transmission disequilibrium testing, to identify immune response genes that influence antibody responses to Plasmodium falciparum infection in an endemic Tanzanian population. Candidate polymorphisms are within the interleukin-1 (IL-1) gene cluster, the IL-10 promoter, Major histocompatibility complex class II and III, the 5q31-q33 region, and the T-Cell Receptor beta variable region. There was a significant association between the IL1RN alleles and total IgE. Weak evidence for association was present between polymorphisms in the IL10 promoter region and both anti-P falciparum IgE and IgG4 antibodies. © 2007 American Society for Histocompatibility and Immunogenetics.
Authors & Co-Authors
Carpenter, Danielle
United Kingdom, Leeds
University of Leeds
Abushama, Hind M.
United Kingdom, Leeds
University of Leeds
Bereczky, Sándor
Sweden, Stockholm
Karolinska Universitetssjukhuset
Färnert, Anna
Sweden, Stockholm
Karolinska Universitetssjukhuset
Rooth, Ingegerd B.
Tanzania, Dar es Salaam
Nyamisati Malaria Research Unit
Troye-Blomberg, Marita
Sweden, Stockholm
Stockholms Universitet
Quinnell, Rupert J.
United Kingdom, Leeds
University of Leeds
Shaw, Marie Anne
United Kingdom, Leeds
University of Leeds
Statistics
Citations: 25
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.humimm.2006.12.002
ISSN:
01988859
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study