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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical features of candidiasis in patients with inherited interleukin 12 receptor β1 deficiency
Clinical Infectious Diseases, Volume 58, No. 2, Year 2014
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Description
Background. Interleukin 12Rβ1 (IL-12Rβ1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin 12-dependent interferon production. About 25% of patients also display mucocutaneous candidiasis, probably owing to impaired interleukin 23-dependent interleukin 17 immunity. The clinical features and outcome of candidiasis in these patients have not been described before, to our knowledge. We report here the clinical signs of candidiasis in 35 patients with IL-12Rβ1 deficiency.Results. Most (n = 71) of the 76 episodes of candidiasis were mucocutaneous. Isolated oropharyngeal candidiasis (OPC) was the most common presentation (59 episodes, 34 patients) and was recurrent or persistent in 26 patients. Esophageal candidiasis (n = 7) was associated with proven OPC in 2 episodes, and cutaneous candidiasis (n = 2) with OPC in 1 patient, whereas isolated vulvovaginal candidiasis (VVC; n = 3) was not. Five episodes of proven invasive candidiasis were documented in 4 patients; 1 of these episodes was community acquired in the absence of any other comorbid condition. The first episode of candidiasis occurred earlier in life (median age±standard deviation, 1.5 ± 7.87 years) than infections with environmental mycobacteria (4.29 ± 11.9 years), Mycobacterium tuberculosis (4 ± 3.12 years), or Salmonella species (4.58 ± 4.17 years) or other rare infections (3 ± 11.67 years). Candidiasis was the first documented infection in 19 of the 35 patients, despite the vaccination of 10 of these 19 patients with live bacille Calmette-Guérin.Conclusions. Patients who are deficient in IL-12Rβ1 may have candidiasis, usually mucocutaneous, which is frequently recurrent or persistent. Candidiasis may be the first clinical manifestation in these patients. © The Author 2013.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3871796/bin/supp_58_2_204__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3871796/bin/supp_cit722_cit722supp.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3871796/bin/supp_cit722_cit722supp_fig1.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3871796/bin/supp_cit722_cit722supp_fig2.tif
Authors & Co-Authors
Ouederni, Monia
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Tunisia, Tunis
Faculté de Médecine de Tunis
Sanal, Özden Z.
Turkey, Ankara
Ankara Üniversitesi
Ikincioǧullarí, Aydan İ.
Turkey, Ankara
Hacettepe Üniversitesi
Tezcan, Ilhan
Turkey, Ankara
Ankara Üniversitesi
Dogu, F. E.
Turkey, Ankara
Hacettepe Üniversitesi
Sologuren, Ithaisa
Japan
Gran Canaria dr Negrín University Hospital
Pedraza-Sánchez, Sigifredo
Spain
Unit of Biochemistry
Emiroǧlu, Melike Keser
Turkey, Istanbul
İstanbul Tıp Fakültesi
Tanír, Gön̈ul
Turkey
Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Center
Nieuwhof, Chris
Netherlands, Maastricht
Maastricht Universitair Medisch Centrum+
Colino-Gil, María Elena
Unknown Affiliation
Kumararatne, Dinakantha S.
United Kingdom, Cambridge
Addenbrooke's Hospital
Levy, Jacob
Israel, Beer-sheva
Ben-gurion University of the Negev
Kütükçüler, Necil
Turkey, Izmir
Ege University Medical School
Aytekin, Caner
Turkey, Ankara
Dr. Sami Ulus Children's Hospital
Herrera-Ramos, Estefanía
Japan
Gran Canaria dr Negrín University Hospital
Bhatti, Micah
United States, Chicago
Comer Children's Hospital - Hyde Park
Edeer-Karaca, Neslihan
Turkey, Izmir
Ege University Medical School
Barbouche, Mohamed Ridha
Tunisia, Tunis
Institut Pasteur de Tunis
Broides, Arnon
Israel, Beer-sheva
Ben-gurion University of the Negev
Goudouris, Ekaterini
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
Franco, Josè Luis
Colombia, Medellin
Universidad de Antioquia
Parvaneh, Nima
Iran, Tehran
Tehran University of Medical Sciences
Reisli, Ïsmail
Turkey, Meram
Necmettin Erbakan Üniversitesi
Strickler, Alexis
Chile, Puerto Montt
Hospital Puerto Montt
Shcherbina, Anna Yu
Russian Federation, Moscow
Oncology
Somer, Ayper M.
Turkey, Istanbul
İstanbul Tıp Fakültesi
Segal, Anthony W.
United Kingdom, London
University College London
Angel-Moreno, Alfonso
Spain, Las Palmas de Gran Canaria
Complejo Hospitalario Universitario Insular Materno-infantil
Lezana-Fernandez, José Luis
Mexico, Mexico
Hospital Infantil de México Federico Gómez
Béjaoui, Mohamed
Tunisia, Tunis
Centre National de Greffe de Moelle Osseuse
Tunisia, Tunis
Faculté de Médecine de Tunis
Del Valle, Miriam Bobadilla
Mexico
National Institute of Medical Sciences and Nutrition Salvador Zubirán (incmnsz
Kachboura, Salem
Tunisia, Tunis
Ariana Hospital
Sentongo, Timothy
United States, Chicago
The University of Chicago Medicine
Ben-Mustapha, Imen
Tunisia, Tunis
Institut Pasteur de Tunis
Bustamante, Jacinta Cecilia
Switzerland
Institut National de la Santé et de la Recherche Médicale
France, Paris
Université Paris Cité
Pïcard, Capucine
Switzerland
Institut National de la Santé et de la Recherche Médicale
France, Paris
Université Paris Cité
France, Paris
Hôpital Necker Enfants Malades
Puel, Anne
Switzerland
Institut National de la Santé et de la Recherche Médicale
France, Paris
Université Paris Cité
Boisson-Dupuis, Stéphanie
United States, New York
Rockefeller University
Switzerland
Institut National de la Santé et de la Recherche Médicale
France, Paris
Université Paris Cité
Abel, Laurent
United States, New York
Rockefeller University
Switzerland
Institut National de la Santé et de la Recherche Médicale
France, Paris
Université Paris Cité
Casanova, Jean Laurent
United States, New York
Rockefeller University
Switzerland
Institut National de la Santé et de la Recherche Médicale
France, Paris
Université Paris Cité
France, Paris
Hôpital Necker Enfants Malades
Rodríguez-Gallego, Carlos
Japan
Gran Canaria dr Negrín University Hospital
Spain, Las Palmas de Gran Canaria
Universidad de Las Palmas de Gran Canaria
Statistics
Citations: 100
Authors: 42
Affiliations: 32
Identifiers
Doi:
10.1093/cid/cit722
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Health System And Policy
Infectious Diseases