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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis: A study in Spanish and Italian populations and meta-analysis
Arthritis and Rheumatism, Volume 63, No. 7, Year 2011
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Description
Objective The LCE3C-LCE3B-del variant is associated with psoriasis and rheumatoid arthritis. Its role in psoriatic arthritis (PsA) is unclear, however, as shown by 3 recent studies with contradictory results. In order to investigate whether LCE3C-LCE3B-del constitutes a risk factor for PsA susceptibility, we first tested this variant in patients with PsA from Spanish and Italian populations and then performed a meta-analysis including the previous case-control studies. Methods We genotyped LCE3C-LCE3B-del and its tag single-nucleotide polymorphism (SNP), rs4112788, in an original discovery cohort of 424 Italian patients with PsA and 450 unaffected control subjects. A Spanish replication cohort consisting of 225 patients with PsA and 469 control subjects was also genotyped. A meta-analysis considering 7,758 control subjects and 2,325 patients with PsA was also performed. Results We observed a significant association between PsA and the LCE3C-LCE3B-del tag SNP in the Italian and Spanish cohorts, with an overall corrected P value of 0.00019 and a corresponding odds ratio of 1.35 (95% confidence interval 1.14-1.59). Stratified analyses by subphenotype indicated a stronger association for patients with oligoarticular disease. Meta-analysis including data from all previous published studies confirmed an association of PsA with the LCE3C-LCE3B-del tag SNP. Conclusion LCE3C-LCE3B-del is a susceptibility factor for PsA, confirming the existence of a shared risk factor involving the epidermal skin barrier in autoimmune disorders. Copyright © 2011 by the American College of Rheumatology.
Authors & Co-Authors
Docampo, Elisa
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Giardina, Emiliano
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
de Cid, Rafael
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Escaramis, Georgia
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Fernández-Sueiro, José Luís
Spain, Corunna
Complejo Hospitalario Universitario Juan Canalejo
González-Gay, Miguel Ángel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Blanco, F. J.
Spain, Corunna
Complejo Hospitalario Universitario Juan Canalejo
Hüffmeier, Ulrike
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Martin, Javier
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Carracedo, Ángel M.
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Reis, André
Germany, Erlangen
Friedrich-alexander-universität Erlangen-nürnberg
Rabionet, Raquel
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Barcelona
Centro de Regulacion Genomica, Barcelona
Novelli, Giuseppe
Italy, Rome
Università Degli Studi Di Roma Tor Vergata
Estivill, Xavier
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Statistics
Citations: 42
Authors: 14
Affiliations: 10
Identifiers
Doi:
10.1002/art.30340
ISSN:
15290131
Study Design
Cohort Study
Case-Control Study
Study Approach
Systematic review