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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Hodgkin's disease in 50 intravenous drug users with HIV-infection
Leukemia and Lymphoma, Volume 3, No. 5-6, Year 1991
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Description
Fifty cases of Hodgkin's disease in intravenous drug users (IVDU) have been collected by the Italian Cooperative Group on AIDS-Related Tumors (G.I.C.A.T.). Ninety-two per cent of the patients were males; the median age was 26 years. Persistent generalized lymphadenopathy (PGL) at onset was present in 54% of patients, AIDS in 9%, ARC in 9% while 28% were simply HIV-positive. The initial median absolute number of CD4 lymphocytes was 264/mmc. Opportunistic infections were diagnosed in 20% of patients. In most patients the histological pattern was that of mixed cellularity and lymphocytic depletion (76%). In almost half the initial symptom was a persistent lymph node enlargement due to PGL. In the majority of patients (58%) only a clinical staging and bone marrow biopsy could be performed due to the presence of opportunistic infections, rapid disease progression or refusal of pathologic staging procedures. One patient presented with a Waldeyer's ring involvement, but no other unusual presentations were observed. After MOPP alternated or followed by ABVD or MOPP alone, 15/29 CR (52%) and 14/29 PR (48%) were observed. The median duration of CR was 14 months, while the median survival of CR has not been reached; the median survival of patients treated with chemotherapy with CD4 values at presentation {geq}400/mmc was significantly superior to that in those with CD4 < 400/mmc. The overall median survival was 16 months. Twenty-eight per cent of patients receiving chemotherapy + radiotherapy developed opportunistic as well as non-opportunistic infections (21%). Lethal hepatic toxicity was observed in 2 patients. In conclusion, Hodgkin's disease in IVDU was not found to be associated with unusual presentations, as previously reported for homosexuals. Complete remissions could be achieved in over 50% of patients, but in IVDU non-opportunistic infections in addition to opportunistic infections may also limit treatment administration. The presence of parenchymal functional impairment due to drug abuse, or drug abuse-related infections, such as pneumonia, endocarditis and hepatitis, should lead to the choice of antitumour agents with no or only minor potential liver, lung and cardiac toxicity. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Authors & Co-Authors
Monfardini, Silvio
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Rezza, Giovanni
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Talamini, Renato
Italy, Aviano
Irccs Centro Di Riferimento Oncologico Aviano
Barbui, Tiziano
Italy, Bergamo
Ospedale Di Bergamo
Bernasconi, Carlo
Italy, Pavia
Fondazione Irccs Policlinico San Matteo
Clerici, Mario S.
Italy, Milan
Azienda Ospedaliera San Carlo Borromeo
Lazzarin, Adriano
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Mandelli, Franco
Unknown Affiliation
Puppo, Francesco
Italy, Genoa
Università Degli Studi Di Genova
Rizzardini, Giuliano
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Rizzi, Marco
Italy, Bergamo
Ospedali Riuniti Di Bergamo
Rossi, Elena Giulia
Unknown Affiliation
Sinicco, Alessandro
Italy, Turin
Università Degli Studi Di Torino
Foà, Roberto
Italy, Turin
Università Degli Studi Di Torino
Statistics
Citations: 3
Authors: 14
Affiliations: 22
Identifiers
Doi:
10.3109/10428199109070281
ISSN:
10428194
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Noncommunicable Diseases
Substance Abuse