Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The impact of tongue-deviating and tongue-depressing oral stents on long-term radiation-associated symptoms in oropharyngeal cancer survivors
Clinical and Translational Radiation Oncology, Volume 24, Year 2020
Notification
URL copied to clipboard!
Description
Objectives: To evaluate whether the use of oral stents during intensity modulated radiation therapy (IMRT) for oropharyngeal cancer (OPC) is associated with long-term patient reported symptoms. Materials and methods: Data was obtained from a prospective observational study of disease-free head and neck cancer survivors. Radiation-associated patient reported symptoms were assessed using the MD Anderson Symptom Inventory Head and Neck module (MDASI-HN). Scores of ≥5 (11-point Likert scale, 0-10) were considered moderate/severe. Stratification was performed regarding IMRT volume (uni- versus bilateral neck) and stent utilization, with non-parametric analyses between groups. Results: 462 OPC survivors formed the cohort (54% tonsil, 46% base of tongue primaries). A tongue-deviating stent was used in 17%, tongue-depressing stent in 46%, and no stent in 37%. Median prescribed dose to the high dose clinical target volume was 66.0 Gy. Median follow-up from RT to MDASI-HN assessment was 68 months. Twenty percent had received unilateral neck RT (all had tonsil primaries), in whom a significant improvement in the proportion of patients with moderate/severe taste impairment (2% vs. 15%, p = 0.047) and lack of appetite (0% vs. 9%, p = 0.019) was associated with the use of tongue-deviating stents compared to no oral stent. In those who had received bilateral neck RT, a significant improvement in the proportion of patients with moderate/severe difficulty swallowing/chewing was associated with use of a tongue-depressing stent (21% vs. 31% without oral stent, p = 0.013). Conclusion: Disease-site specific select use of oral stents during IMRT was associated with reduced long-term patient reported symptoms in OPC survivors. © 2020 The Authors
Authors & Co-Authors
Stieb, Sonja
United States, Houston
The University of Texas Md Anderson Cancer Center
Mohamed, Abdallah Sherif Radwan
United States, Houston
The University of Texas Md Anderson Cancer Center
Garden, Adam Seth
United States, Houston
The University of Texas Md Anderson Cancer Center
Goepfert, Ryan P.
United States, Houston
The University of Texas Md Anderson Cancer Center
Cardoso, Richard C.
United States, Houston
The University of Texas Md Anderson Cancer Center
Ferrarotto, Renata
United States, Houston
The University of Texas Md Anderson Cancer Center
Reddy, Jay Paul
United States, Houston
The University of Texas Md Anderson Cancer Center
Phan, Jack
United States, Houston
The University of Texas Md Anderson Cancer Center
Morrison, William H.
United States, Houston
The University of Texas Md Anderson Cancer Center
Rosenthal, David I.
United States, Houston
The University of Texas Md Anderson Cancer Center
Koay, Eugene Jon
United States, Houston
The University of Texas Md Anderson Cancer Center
Frank, Steven J.
United States, Houston
The University of Texas Md Anderson Cancer Center
Fuller, Clifton David
United States, Houston
The University of Texas Md Anderson Cancer Center
Gunn, G. Brandon
United States, Houston
The University of Texas Md Anderson Cancer Center
Statistics
Citations: 11
Authors: 14
Affiliations: 1
Identifiers
Doi:
10.1016/j.ctro.2020.05.014
ISSN:
24056308
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study