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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The AG recombinant IbNG and novel strains of group M HIV-1 are common in Cameroon
Virology, Volume 286, No. 1, Year 2001
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Description
The genetic diversity of group M HIV-1 is highest in west central Africa. Blood samples from four locations in Cameroon were collected to determine the molecular epidemiology of HIV-1. The C2-V5 region of envelope was sequenced from 39 of the 40 samples collected, and 7 samples were sequenced across the genome. All strains belonged to group M of HIV-1. The circulating recombinant form CRF02_AG (IbNG) was the most common strain (22/39, 56%). Two of these were confirmed by full genome analysis. Four samples (4/39, 10%) clustered with the sub-subtype F2 and one of these was confirmed by full genome sequencing. Recombinant forms, each different but containing subtype A, accounted for the next most common form (7/39, 18%). Among these recombinants, those combining subtypes A and G were the most common (4/7, 57%). Also found were 3 subtype A, 2 subtype G, and 1 subtype B strain. Many recombination break points were shared between IbNG and the other AG recombinants, though none of these other AG recombinants included IbNG as a parent. This suggests that there was an ancestral AG recombinant that gave rise to CRF02_AG (IbNG), the successful circulating recombinant form, and to others that were less successful and are now rare. © 2001 Academic Press.
Authors & Co-Authors
Carr, Jean Kirkland
United States, Rockville
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Torimiro, Judith Ndongo
Cameroon, Yaounde
Hôpital Militaire
Wolfe, Nathan D.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Eitel, Mpoudi Ngole
Cameroon, Yaounde
Hôpital Militaire
Kim, Bohye
United States, Rockville
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Sanders-Buell, Eric E.
United States, Rockville
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Jagodzinski, Linda L.
United States, Rockville
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Gotte, Deanna R.
United States, Rockville
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Burke, Donald S.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Birx, Deborah L.
United States, Silver Spring
Walter Reed Army Institute of Research
McCutchan, Francine E.
United States, Rockville
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Statistics
Citations: 88
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1006/viro.2001.0976
ISSN:
00426822
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Cameroon