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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High prevalence of screen detected prostate cancer in West Africans: Implications for racial disparity of prostate cancer
Journal of Urology, Volume 192, No. 3, Year 2014
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Description
Purpose To our knowledge the reasons for the high rates of prostate cancer in black American men are unknown. Genetic and lifestyle factors have been implicated. Better understanding of prostate cancer rates in West African men would help clarify why black American men have such high rates since the groups share genetic ancestry and yet have different lifestyles and screening practices. To estimate the prostate cancer burden in West African men we performed a population based screening study with biopsy confirmation in Ghana. Materials and Methods We randomly selected 1,037 healthy men 50 to 74 years old from Accra, Ghana for prostate cancer screening with prostate specific antigen testing and digital rectal examination. Men with a positive screen result (positive digital rectal examination or prostate specific antigen greater than 2.5 ng/ml) underwent transrectal ultrasound guided biopsies. Results Of the 1,037 men 154 (14.9%) had a positive digital rectal examination and 272 (26.2%) had prostate specific antigen greater than 2.5 ng/ml, including 166 with prostate specific antigen greater than 4.0 ng/ml. A total of 352 men (33.9%) had a positive screen by prostate specific antigen or digital rectal examination and 307 (87%) underwent biopsy. Of these men 73 were confirmed to have prostate cancer, yielding a 7.0% screen detected prostate cancer prevalence (65 patients), including 5.8% with prostate specific antigen greater than 4.0 ng/ml. Conclusions In this relatively unscreened population in Africa the screen detected prostate cancer prevalence is high, suggesting a possible role of genetics in prostate cancer etiology and the disparity in prostate cancer risk between black and white American men. Further studies are needed to confirm the high prostate cancer burden in African men and the role of genetics in prostate cancer etiology. © 2014 by American Urological Association Education and Research, Inc.
Authors & Co-Authors
Hsing, Ann Wu
United States, Fremont
Cancer Prevention Institute of California
United States, Stanford
Stanford Cancer Institute
United States, Stanford
Stanford University School of Medicine
United States, Rockville
National Cancer Institute Nci
Yeboah, Edward D.
Ghana, Accra
University of Ghana
Biritwum, Richard Berko
Ghana, Accra
University of Ghana
Tettey, Yao
Ghana, Accra
University of Ghana
DeMarzo, A.
United States, Baltimore
Johns Hopkins School of Medicine
Adjei, Andrew Anthony
Ghana, Accra
University of Ghana
Netto, G.
United States, Baltimore
Johns Hopkins School of Medicine
Yu, Kai
United States, Rockville
National Cancer Institute Nci
Li, Yan
United States, Rockville
National Cancer Institute Nci
Chokkalingam, Anand P.
United States, Berkeley
University of California, Berkeley
Chu, Lisa W.
United States, Fremont
Cancer Prevention Institute of California
United States, Stanford
Stanford Cancer Institute
Chia, D.
United States, Los Angeles
University of California, Los Angeles
Partin, Alan Wayne
United States, Baltimore
Johns Hopkins School of Medicine
Thompson, Ian Murchie
United States, San Antonio
University of Texas Health Science Center at San Antonio
Quraishi, Sabah M.
United States, Rockville
National Cancer Institute Nci
Niwa, Shelley
United States, Rockville
Westat, Inc.
Tarone, Robert
United States, Rockville
International Epidemiology Institute
Hoover, Robert N.
United States, Rockville
National Cancer Institute Nci
Statistics
Citations: 18
Authors: 18
Affiliations: 11
Identifiers
Doi:
10.1016/j.juro.2014.04.017
ISSN:
00225347
e-ISSN:
15273792
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Ghana
Participants Gender
Male