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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Association between plasma levels of transforming growth factor-β1, IL-23 and IL-17 and the severity of autism in Egyptian children
Research in Autism Spectrum Disorders, Volume 7, No. 1, Year 2013
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Description
It has been recently shown that dysregulation of transforming growth factor-β1 (TGF-β1), IL-23 and IL-17 has been identified as a major factor involved in autoimmune disorders. Based on the increasing evidence of immune dysfunction in autism the aim of this study was to measure serum levels of TGF-β 1, IL-23 and IL-17 in relation to the degree of the severity of autism. Serum TGF-β1, IL-23 and IL-17 were measured by Enzyme-linked Immunosorbent Assay technique in 50 autistic children aged 6-12 years, in comparison to 50 developmental disabilities and 50 typically developing-matched children. The severity of autism was assessed by using the Childhood Autism Rating Scale. We found that TGF-β1 and IL-23 levels were significantly decreased in the plasma of children with ASD in comparison to control groups (P < 0.0001 for both) with no significant difference in IL-17 levels. There was no correlation between IL-23 and TGF-β1 with IL-17 in children with ASD. There was a negative correlation between TGF-β1, IL-23 and IL-17 with the severity of autism (P < 0.0001, 0.0001, 0.005 respectively). Our results support the findings that immune dysfunction may occur in some children with autism. © 2012 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Hashim, Haitham Mohammed
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Abdelrahman, Hadeel M.
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Youssef, Doaa Mohammed
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Karam, R. A.
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Statistics
Citations: 29
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/j.rasd.2012.08.007
ISSN:
17509467
e-ISSN:
18780237
Research Areas
Disability
Maternal And Child Health