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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Preferential expression of domain cassettes 4, 8 and 13 of Plasmodium falciparum erythrocyte membrane protein 1 in severe malaria imported in France
Clinical Microbiology and Infection, Volume 23, No. 3, Year 2017
Notification
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Description
Objectives Severe Plasmodium falciparum malaria (SM) involves cytoadhesion of parasitized red blood cells, mediated by P. falciparum erythrocyte membrane protein 1, which is encoded by var genes. Expression of var gene group A and B or encoding domain cassettes DC4, DC5, DC8 and DC13 has been implicated in SM in African children, but no data exist in the context of imported malaria. The aim of this study was to investigate var gene expression linked to clinical presentation and host factors in SM imported into France. Methods Expression level of var gene groups A, B, C, var1, var2csa, var3 and var genes encoding DC4, DC5, DC8 and DC13 was measured by quantitative RT-PCR and expressed in transcript units. Seventy SM and 48 uncomplicated malaria (UM) P. falciparum cases were analysed according to disease severity, epidemiological characteristics (migrants or travellers) and anti-P. falciparum antibodies. Cluster analysis was performed to identify gene expression profiles. Results Var1 and B/C expression were higher in UM than SM (0.66 (0–1.1) and 1.88 (1.3–2.4); p <0.04, respectively). Group C expression differed between migrants and travellers (0.21 (0–0.75) versus 0 (0–0); p 0.002). Group A differed in naive and pre-exposed patients (1.1 (0.7–1.5) versus 0.4 (0–1.1); p 0.01). Population clusters revealed increased expression from group A and B var genes, and DC4, DC8 and DC13 in SM. Conclusions These results corroborate the implication of DC4, DC8 and DC13 in severe imported malaria cases as African children, and their expression depends of host factors. © 2016 European Society of Clinical Microbiology and Infectious Diseases
Authors & Co-Authors
Argy, Nicolas
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
France, Paris
Mère et Enfant en Milieu Tropical : Pathogènes, Système de Santé et Transition Epidémiologique
Bertin, Gwladys I.
France, Paris
Université Paris Cité
France, Paris
Mère et Enfant en Milieu Tropical : Pathogènes, Système de Santé et Transition Epidémiologique
Milet, Jacqueline
France, Paris
Université Paris Cité
France, Paris
Mère et Enfant en Milieu Tropical : Pathogènes, Système de Santé et Transition Epidémiologique
Hubert, Véronique
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Clain, Jérôme
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
France, Paris
Mère et Enfant en Milieu Tropical : Pathogènes, Système de Santé et Transition Epidémiologique
Cojean, Sandrine
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Houzé, Pascal
France, Paris
Université Paris Cité
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Tuikue-Ndam, Nicaise
France, Paris
Université Paris Cité
France, Paris
Mère et Enfant en Milieu Tropical : Pathogènes, Système de Santé et Transition Epidémiologique
Kendjo, Éric
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Deloron, Philippe
France, Paris
Université Paris Cité
France, Paris
Mère et Enfant en Milieu Tropical : Pathogènes, Système de Santé et Transition Epidémiologique
Houzé, Sandrine
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
France, Paris
Mère et Enfant en Milieu Tropical : Pathogènes, Système de Santé et Transition Epidémiologique
Matheron, Sophie
Unknown Affiliation
Wolff, Michel A.
Unknown Affiliation
Agnamey, Patrice P.
Unknown Affiliation
Durand, Rémy
Unknown Affiliation
Rapp, Christophe
Unknown Affiliation
Faucher, Jean François
Unknown Affiliation
de Gentile, Ludovic
Unknown Affiliation
Lohmann, Caroline
Unknown Affiliation
Dunand, Jean
Unknown Affiliation
Enache-Angoulvant, Adéla
Unknown Affiliation
Murat, Jean Benjamin
Unknown Affiliation
Garnaud, Cécile
Unknown Affiliation
Dannaoui, Eric
Unknown Affiliation
Botterel, Francoise
Unknown Affiliation
Dutoit, Emmanuel
Unknown Affiliation
Dardé, Marie Laure
Unknown Affiliation
Branger, Catherine
Unknown Affiliation
Angebault, Cécile
Unknown Affiliation
Morio, Florent
Unknown Affiliation
Thellier, Marc
Unknown Affiliation
Mouri, Oussama
Unknown Affiliation
Cateau, Estelle
Unknown Affiliation
Fenneteau, Odile
Unknown Affiliation
Hamane, Samia
Unknown Affiliation
Bretagne, Stéphane
Unknown Affiliation
Aboubacar, Ahmed
Unknown Affiliation
Develoux, Michel
Unknown Affiliation
Nevez, Gilles
Unknown Affiliation
Desoubeaux, Guillaume
Unknown Affiliation
Statistics
Citations: 5
Authors: 40
Affiliations: 3
Identifiers
Doi:
10.1016/j.cmi.2016.10.012
ISSN:
1198743X
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative