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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albendazole in a highly endemic area
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 89, No. 5, Year 1995
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Description
The comparative efficacy of albendazole and mebendazole in the treatment of intestinal nematode infections were compared 3 weeks after treatment in a randomized trial among schoolchildren on Pemba Island, Tanzania. Egg counts were compared 3 weeks, 4 months and 6 months after treatment of 731 children seen on each occasion. Differences in the efficacies were apparent with some nematodes 21 d after treatment, but these were no longer apparent 4 months after treatment, and by 6 months intensities of infection were similar to pre-treatment levels. These findings suggest that treatment of schoolchildren every 4 months may be necessary in this highly endemic area in order to have an impact on the intensity of intestinal nematode infections sufficient to be likely to reduce morbidity. © 1995 Oxford University Press.
Authors & Co-Authors
Albonico, Marco
Unknown Affiliation
Smith, Peter George
Unknown Affiliation
Ercole, E.
Unknown Affiliation
Hall, Andrew J.
Unknown Affiliation
Chwaya, Hababu Mohammed
Unknown Affiliation
Alawi, Kassim S.
Unknown Affiliation
Savioli, Lorenzo
Unknown Affiliation
Statistics
Citations: 183
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1016/0035-9203(95)90101-9
ISSN:
00359203
e-ISSN:
18783503
Research Areas
Maternal And Child Health
Study Locations
Tanzania