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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Activated mouse CD4 + Foxp3 - T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity
Cell Research, Volume 22, No. 12, Year 2012
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Description
The regulatory activities of mouse CD4 + Foxp3 + + T cells on various immune cells, including NK cells, have been well documented. Under some conditions, conventional CD4 + Foxp3 - T cells in the periphery are able to acquire inhibitory function on other T cells, but their roles in controlling innate immune cells are poorly defined. As a potential cellular therapy for cancer, ex vivo activated CD4 + Foxp3 - effector T cells are often infused back in vivo to suppress tumor growth and metastasis. Whether such activated T cells could affect NK-cell control of tumorigenesis is unclear. In the present study, we found that mitogen-activated CD4 + Foxp3 - T cells exhibited potent suppressor function on NK-cell proliferation and cytotoxicity in vitro, and notably facilitated B16 melanoma metastasis in vivo. Suppression of NK cells by activated CD4 + Foxp3 - T cells is cell-cell contact dependent and is mediated by Qa-1:NKG2A interaction, as administration of antibodies blocking either Qa-1 or NKG2A could completely reverse this suppression, and significantly inhibited otherwise facilitated melanoma metastasis. Moreover, activated CD4 + Foxp3 - cells from Qa-1 knockout mice completely lost the suppressor activity on NK cells, and failed to facilitate melanoma metastasis when transferred in vivo. Taken together, our findings indicate that innate anti-tumor response is counter regulated by the activation of adaptive immunity, a phenomenon we term as activation-induced inhibition. Thus, the regulatory role of activated CD4 + Foxp3 - T cells in NK-cell activity must be taken into consideration in the future design of cancer therapies. © 2012 IBCB, SIBS, CAS All rights reserved.
Authors & Co-Authors
Luo, Gaoxing
China, Chongqing
Third Military Medical University
He, Weifeng
China, Chongqing
Third Military Medical University
Robson, Simon Christopher
United States, Boston
Beth Israel Deaconess Medical Center
Li, Xianchang
United States, Boston
Beth Israel Deaconess Medical Center
Gao, Wenda
Unknown Affiliation
Statistics
Citations: 13
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1038/cr.2012.128
ISSN:
17487838
Research Areas
Cancer