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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Influences of Age, Sex, and Moderate Alcohol Drinking on the Intrinsic Functional Architecture of Adolescent Brains
Cerebral Cortex, Volume 28, No. 3, Year 2018
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Description
The transition from adolescent to adult cognition and emotional control requires neurodevelopmental maturation likely involving intrinsic functional networks (IFNs). Normal neurodevelopment may be vulnerable to disruption from environmental insult such as alcohol consumption commonly initiated during adolescence. To test potential disruption to IFN maturation, we used resting-state functional magnetic resonance imaging (rs-fMRI) in 581 no-to-low alcohol-consuming and 117 moderate-to-high-drinking youth. Functional seed-to-voxel connectivity analysis assessed age, sex, and moderate alcohol drinking on default-mode, executive-control, salience, reward, and emotion networks and tested cognitive and motor coordination correlates of network connectivity. Among no-to-low alcohol-consuming adolescents, executive-control frontolimbicstriatal connectivity was stronger in older than younger adolescents, particularly boys, and predicted better ability in balance, memory, and impulse control. Connectivity patterns in moderate-to-high-drinking youth were tested mainly in late adolescence when drinking was initiated. Implicated was the emotion network with attenuated connectivity to default-mode network regions. Our cross-sectional rs-fMRI findings from this large cohort of adolescents show sexual dimorphism in connectivity and suggest neurodevelopmental rewiring toward stronger and spatially more distributed executive-control networking in older than younger adolescents. Functional network rewiring in moderate-to-high-drinking adolescents may impede maturation of affective and self-reflection systems and obscure maturation of complex social and emotional behaviors. © 2017 The Author.
Authors & Co-Authors
Müller-Oehring, Eva M.
United States, Menlo Park
Sri International
United States, Stanford
Stanford University School of Medicine
Kwon, Dongjin
United States, Menlo Park
Sri International
United States, Stanford
Stanford University School of Medicine
Nagel, Bonnie J.
United States, Portland
Oregon Health & Science University
Sullivan, Edith V.
United States, Stanford
Stanford University School of Medicine
Rohlfing, Torsten
United States, Menlo Park
Sri International
Prouty, Devin E.
United States, Menlo Park
Sri International
Poline, Jean Baptiste
United States, Berkeley
University of California, Berkeley
Tapert, Susan Frances
United States, La Jolla
University of California, San Diego
Brown, Sandra A.
United States, La Jolla
University of California, San Diego
Brumback, Ty Y.
United States, La Jolla
University of California, San Diego
Colrain, Ian M.
United States, Menlo Park
Sri International
Baker, Fiona C.
United States, Menlo Park
Sri International
de Bellis, Michael D.
United States, Durham
Duke University School of Medicine
Clark, Duncan B.
United States, Pittsburgh
University of Pittsburgh
Pfefferbaum, Adolf
United States, Menlo Park
Sri International
United States, Stanford
Stanford University School of Medicine
Pohl, Kilian M.
United States, Menlo Park
Sri International
Statistics
Citations: 27
Authors: 16
Affiliations: 7
Identifiers
Doi:
10.1093/cercor/bhx014
ISSN:
10473211
Research Areas
Sexual And Reproductive Health
Substance Abuse
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male