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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Lymphocytic choriomeningitis virus and fetal anomalies
Pathologie Biologie, Volume 59, No. 4, Year 2011
Notification
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Description
Objective: Lymphocytic choriomeningitis virus (LCMV), a rodent-borne arenavirus, is an uncommonly recognized cause of severe congenital viral infection. The incidence of this infection during pregnancy is still unknown. Our study aimed to evaluate LCMV infection frequency in pregnancy with fetal neurological abnormalities of unknown etiology. Material and methods: Samples obtained during three years from 160 pregnant women were retrospectively analysed: 155 maternal sera, 150 amniotic fluids (AF) and 12 fetal sera (FS). Congenital neurological anomalies were diagnosed but TORCH and culture investigations were negatives. Serological analysis was performed with L929 cells infected with the Armstrong strain of LCMV. IgG and IgM antibodies against CMLV were researched by immunofluorescence assay using these infected cells. Interferon alpha was also assayed for AF and FS. Results: No positive serology was found in any of the 317 samples investigated even when interferon alpha was detected. Conclusion: This result confirms the rarity of LCMV infection in France. Nevertheless, at the light of the recent literature, this teratogenic pathogen should be considered in pregnancy with unexplained congenital malformation, especially after rodent exposure. © 2009 Elsevier Masson SAS.
Authors & Co-Authors
Hannachi, Naila
France, Paris
Hopital Cochin Ap-hp
Tunisia, Sousse
Hopital Farhat Hached Sousse
Freymuth, François L.
France, Caen
Chu de Caen Normandie
Luton, Dominique
France, Clichy
Hôpital Beaujon
Herlicoviez, M.
France, Caen
Chu de Caen Normandie
Oury, Jean François
France, Clichy
Service de Gyncologie Obsttrique
Boukadida, Jalel
Tunisia, Sousse
Hopital Farhat Hached Sousse
Lebon, Pierre
France, Paris
Hopital Cochin Ap-hp
Statistics
Citations: 7
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1016/j.patbio.2009.06.001
ISSN:
03698114
e-ISSN:
17683114
Research Areas
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Participants Gender
Female