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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Topical application of oxifulvic acid suppresses the cutaneous immune response in mice
Drug Development Research, Volume 53, No. 1, Year 2001
Notification
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Description
The antiinflammatory activity of topically applied coal-derived fulvic acids (called oxifulvic acid) at 4.5% and 9% was compared with that of diclofene sodium at 1% and betamethasone at 0.1% in a murine model of contact hypersensitivity. Mice were sensitised with dinitrofluorobenzene and challenged 6 days later by application to the dorsal surface of the right ear. The inflamed ears of the mice were then treated topically, and the thickness of the ears was measured daily. Oxifulvic acid at both concentrations compared favourably with both diclofene sodium and betamethasone in suppressing the cutaneous inflammatory response. Oxifulvic acid possesses antiinflammatory properties and may be of clinical benefit in the treatment of inflammatory skin conditions in humans. © 2001 Wiley-Liss, Inc.
Authors & Co-Authors
Van Rensburg, Constance Elizabeth Jansen
South Africa, Pretoria
Faculty of Health Sciences
South Africa, Pretoria
Enerkom Pty Ltd.
Malfeld, Susan C.K.
South Africa, Pretoria
Faculty of Health Sciences
South Africa, Pretoria
Enerkom Pty Ltd.
Dekker, Johannes
South Africa, Pretoria
Faculty of Health Sciences
South Africa, Pretoria
Enerkom Pty Ltd.
Statistics
Citations: 58
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1002/ddr.1166
ISSN:
02724391