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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
High prevalence of the cytochrome P450 2C8*2 mutation in Northern Ghana
Tropical Medicine and International Health, Volume 10, No. 12, Year 2005
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Description
Recently, Ghana has changed the first-line treatment of uncomplicated malaria from chloroquine to amodiaquine (AQ) plus artesunate. AQ may cause adverse events such as agranulocytosis and hepatoxicity. The pro-drug AQ is transformed by cytochrome P450 CYP2C8 to the active metabolite N-desethylaminodiaquine. Several polymorphic variants of CYP2C8 are known, some with reduced activity. In 200 randomly selected children from Northern Ghana, we determined the allele frequencies of the CYP2C8 variants CYP2C8*1 (wild type), CYP2C8*2, CYP2C8*3, and CYP2C8*4. We did not detect CYP2C8*3 and CYP2C8*4, but CYP2C8*2 showed an allele frequency of 0.1675. AQ metabolism in patients with CYP2C8*2 may be impaired, and with an increase of AQ based treatment the risk of severe adverse events may mount. © 2005 Blackwell Publishing Ltd.
Authors & Co-Authors
Roewer, Susanne
Germany, Berlin
Charité – Universitätsmedizin Berlin
Germany, Berlin
Institute of Tropical Medicine
Bienzle, Ulrich
Germany, Berlin
Charité – Universitätsmedizin Berlin
Germany, Berlin
Institute of Tropical Medicine
Weise, Alexander
Germany, Mainz
Ikfe
Lambertz, Ulrike
Germany, Mainz
Ikfe
Forst, Thomas
Germany, Mainz
Ikfe
Otchwemah, Rowland N.
Ghana, Tamale
University for Development Studies Ghana
Pfútzner, Andreas
Germany, Mainz
Ikfe
Germany, Steinfurt
Fachhochschule Münster - Abteilung Steinfurt
Mockenhaupt, Frank Peter
Germany, Berlin
Charité – Universitätsmedizin Berlin
Germany, Berlin
Institute of Tropical Medicine
Statistics
Citations: 43
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1111/j.1365-3156.2005.01525.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Ghana