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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Lectin binding in human breast cancer: Clinical and pathologic correlations with fluorescein-conjugated peanut, wheat germ and concanavalin a binding
Oncology (Switzerland), Volume 45, No. 4, Year 1988
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Description
Cell surface glycoconjugates of human breast cancer tissue were investigated using FITC peanut (PNA). Wheat germ (WGA) and jackbean (concanavalin A; Con A) agglutinins. Although PNA and WGA binding patterns differed when normal and malignant breast tissues were compared, the specificity of this finding was poor and neither PNA nor WGA binding correlated with oestrogen receptor status or clinical outcome. Con A binding on the other hand was not seen in normal breast tissue. The percentage of Con-A-positive (Con A +) tumours increased progressively with advancing stage (16% Con A+ in stage I, 40% Con A+ in stage III) and there was a trend towards longer disease-free survival of patients with Con A-as compared to those with Con A+ tumours. However, in a multivariate analysis it was found that these differences were explained by the association with the stage of the disease. © 1988 S. Karger AG, Basel.
Authors & Co-Authors
Dansey, Roger Delemere
South Africa, Johannesburg
School of Clinical Medicine
Murray, J.
South Africa, Johannesburg
School of Clinical Medicine
Ninin, Daniel T.
South Africa, Johannesburg
School of Clinical Medicine
Bezwoda, Werner Robert
South Africa, Johannesburg
School of Clinical Medicine
Statistics
Citations: 14
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1159/000226627
ISSN:
00302414
e-ISSN:
14230232
Research Areas
Cancer