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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence
Proceedings of the National Academy of Sciences of the United States of America, Volume 103, No. 24, Year 2006
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Description
Persistent hepatitis B virus infection is a major risk factor for hepatocellular carcinoma, the most frequent cancer in some developing countries. Up to 95% of those infected at birth and 15% of those infected after the neonatal period fail to clear hepatitis B virus, together resulting in ≈350 million persistent carriers worldwide. Via a whole genome scan in Gambian families, we have identified a major susceptibility locus as a cluster of class II cytokine receptor genes on chromosome 21q22. Coding changes in two of these genes, the type IIFN receptor gene, IFN-AR2, and the IL-10RB gene that encodes a receptor chain for IL-10-related cytokines including the IFN-As, are associated with viral clearance (haplotype P value = 0.0003), and in vitro assays support functional roles for these variants in receptor signaling. © 2006 by The National Academy of Sciences of the USA.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1482581/bin/pnas_0602800103_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC1482581/bin/pnas_0602800103_2.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1482581/bin/pnas_0602800103_3.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1482581/bin/pnas_0602800103_4.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1482581/bin/pnas_0602800103_5.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1482581/bin/pnas_0602800103_6.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1482581/bin/pnas_0602800103_7.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1482581/bin/pnas_0602800103_1.pdf
Authors & Co-Authors
Frodsham, A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Zhang, L.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Dumpis, Uga
Gambia, Banjul
Medical Research Council Laboratories Gambia
Taib, Nor Azizah Mohd
United Kingdom, London
St Mary's Hospital
Best, Steve
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Durham, Andrew
United Kingdom, London
St Mary's Hospital
Hennig, Branwen J.W.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Hellier, Simon
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Knapp, Susanne
United Kingdom, London
St Mary's Hospital
Wright, Mark
United Kingdom, London
St Mary's Hospital
Chiaramonte, Maria
Italy, L'aquila
Università Degli Studi Dell'aquila
Bell, John I.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Graves, Mary
United Kingdom, Welwyn Garden City
Roche Products Limited uk
Whittle, Hilton C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Thomas, Howard C.
United Kingdom, London
St Mary's Hospital
Thursz, Mark R.
United Kingdom, London
St Mary's Hospital
United Kingdom, London
Imperial College London
Hill, Adrian V. S.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Statistics
Citations: 109
Authors: 17
Affiliations: 6
Identifiers
Doi:
10.1073/pnas.0602800103
ISSN:
00278424
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Maternal And Child Health