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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
A nascent HIV type 1 epidemic among injecting drug users in Kabul, Afghanistan is dominated by complex AD recombinant strain, CRF35_AD
AIDS Research and Human Retroviruses, Volume 23, No. 6, Year 2007
Notification
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Description
Injecting drug use (IDU), common in global centers of heroin production, confers significant risk for HIV-1 infection. Once introduced into IDU networks, an explosive rise in HIV-1 infection typically occurs, fueled principally by needle sharing. New HIV-1 epidemics in IDUs have occurred in Russia, China, Thailand, Spain, Iran, and in other countries, and some have spread into other risk groups in their respective countries. In Afghanistan, the introduction of HIV-1 into IDU networks has begun, but a recent report of 3% HIV-1 prevalence suggests that the epidemic is still at an early stage. Here we establish, by complete genome sequencing and phylogenetic analysis of four viral strains from Afghan IDUs, that all are the same complex recombinant strain, combining HIV-1 subtypes A and D and herein termed CRF35_AD. Published partial HIV-1 sequences from an HIV-1 epidemic among IDUs in Iran, already at 23.2% HIV-1 prevalence, are either CRF35_AD or a related recombinant. Voluntary HIV-1 screening and harm reduction programs in Afghanistan, applied now, could limit the spread of HIV-1, both in IDUs and in other social networks. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Sanders-Buell, Eric E.
United States, Silver Spring
Walter Reed Army Institute of Research
United States, Rockville
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Saad, Magdi Darwish
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Abed, Abdullah M.S.
Afghanistan, Kabul
Ministry of Public Health
Bose, Meera
United States, Silver Spring
Walter Reed Army Institute of Research
Todd, Catherine S.
United States, La Jolla
University of California, San Diego
Strathdee, Steffanie Anne
United States, La Jolla
University of California, San Diego
Botros, Boulos A.E.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Safi, Naqibullah
Afghanistan, Kabul
Ministry of Public Health
Earhart, Kenneth C.
Egypt, Cairo
U.s. Naval Medical Research Unit No. 3, Egypt
Scott, Paul T.
United States, Silver Spring
Walter Reed Army Institute of Research
Michael, Nelson L.
United States, Silver Spring
Walter Reed Army Institute of Research
McCutchan, Francine E.
United States, Silver Spring
Walter Reed Army Institute of Research
Statistics
Citations: 50
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1089/aid.2006.0299
ISSN:
08892229
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study