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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Impact of mosquito bites on asexual parasite density and gametocyte prevalence in asymptomatic chronic plasmodium falciparum infections and correlation with IgE and IgG titers
Infection and Immunity, Volume 80, No. 6, Year 2012
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Description
An immunomodulatory role of arthropod saliva has been well documented, but evidence for an effect on Plasmodium sp. infectiousness remains controversial. Mosquito saliva may orient the immune response toward a Th2 profile, thereby priming a Th2 response against subsequent antigens, including Plasmodium. Orientation toward a Th1 versus a Th2 profile promotes IgG and IgE proliferation, respectively, where the former is crucial for the development of an efficient antiparasite immune response. Here we assessed the direct effect of mosquito bites on the density of Plasmodium falciparum asexual parasites and the prevalence of gametocytes in chronic, asymptomatic infections in a longitudinal cohort study of seasonal transmission. We additionally correlated these parasitological measures with IgE and IgG antiparasite and anti-salivary gland extract titers. The mosquito biting density was positively correlated with the asexual parasite density but not asexual parasite prevalence and was negatively correlated with gametocyte prevalence. Individual anti-salivary gland IgE titers were also negatively correlated with gametocyte carriage and were strongly positively correlated with antiparasite IgE titers, consistent with the hypothesis that mosquito bites predispose individuals to develop an IgE antiparasite response. We provide evidence that mosquito bites have an impact on asymptomatic infections and differentially so for the production of asexual and sexual parasites. An increased research focus on the immunological impact of mosquito bites during asymptomatic infections is warranted, to establish whether strategies targeting the immune response to saliva can reduce the duration of infection and the onward transmission of the parasite. © 2012, American Society for Microbiology.
Authors & Co-Authors
Lawaly, Ramatoulaye
Senegal, Dakar
Institut Pasteur de Dakar
Konaté, Lassana
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Marrama, Laurence
Senegal, Dakar
Institut Pasteur de Dakar
Dia, Ibrahima K.
Senegal, Dakar
Institut Pasteur de Dakar
Diallo, Diawo
Senegal, Dakar
Institut Pasteur de Dakar
Sarr, Fatoumata Diène
Senegal, Dakar
Institut Pasteur de Dakar
Schneider, Bradley S.
France, Paris
Institut Pasteur, Paris
United States, San Francisco
Global Viral
Casadémont, Isabelle
France, Paris
Institut Pasteur, Paris
Diallo, Mawlouth R.
Senegal, Dakar
Institut Pasteur de Dakar
Brey, Paul Trevor
Laos, Vientiane
Institut Pasteur du Laos
Sakuntabhai, Anavaj
France, Paris
Institut Pasteur, Paris
Thailand, Nakhon Pathom
Mahidol University
Mécheri, Salaheddine
France, Paris
Institut Pasteur, Paris
Paul, Richard P.C.
Senegal, Dakar
Institut Pasteur de Dakar
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 22
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1128/IAI.06414-11
ISSN:
00199567
e-ISSN:
10985522
Research Areas
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative