Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Screening for rheumatic heart disease: Evaluation of a simplified echocardiography-based approach
European Heart Journal Cardiovascular Imaging, Volume 13, No. 12, Year 2012
Notification
URL copied to clipboard!
Description
Aims: Portable echocardiography has emerged as a potential tool to detect rheumatic heart disease (RHD) early. Complex echocardiographic criteria used in recent epidemiological studies may be difficult to translate into daily practice in areas where the burden of RHD is greatest and skilled practitioners are lacking. The aim of this study was to evaluate a simplified echo approach for RHD screening among children in low-income countries.Methods and resultsRetrospective analysis of data from a cross-sectional echocardiography-based study carried out in 2005 through the examination of 2170 school children in Maputo, Mozambique. We aimed to evaluate the value of a reference set of criteria (defined as a combination of Doppler and morphological rheumatic features of the aortic and/or mitral valves) compared with an easy-to-use single mitral regurgitation jet-length criterion (simplified set of criteria). All suspected lesions (according to reference or simplified criteria) detected in the field by a portable echo machine were reassessed by non-portable echocardiography and then read by three independent experts. Definite RHD cases in both groups were finally ascertained according to the reference criteria. Portable echocardiography detected valve regurgitation in 208 children. According to the reference criteria, 18 children were detected with suspected RHD on site. Of these, 15 children (83) were considered to have definite RHD, giving a prevalence of 6.9 per 1000 (95 CI: 3.9-11.4). The simplified mitral regurgitation jet-length criteria detected 12 children at school, 11 of whom were subsequently confirmed to have definite RHD, giving an estimated prevalence of 5.1 per 1000 (95 CI: 2.5-9.1) (P 0.12, exact McNemar test). When compared with the reference criteria, the simplified approach yields a maximum sensitivity of 73 for case detection, with a positive predictive value of 92.ConclusionSimplified echocardiography-based screening for RHD appears feasible, allowing rapid and appropriate detection of a significant number of RHD cases on site.© 2012 Author.
Authors & Co-Authors
Mirabel, Mariana M.
France, Paris
Hôpital Européen Georges-pompidou
France, Paris
Université Paris Cité
United Kingdom, London
University College London
Celermajer, David S.
Australia, Sydney
The University of Sydney School of Medicine
Ferreira, Beatriz
Mozambique, Maputo
Icor
Tafflet, Muriel
France, Paris
Hôpital Européen Georges-pompidou
France, Paris
Université Paris Cité
Périer, Marie Cécile
France, Paris
Hôpital Européen Georges-pompidou
France, Paris
Université Paris Cité
Karam, Nicole
France, Paris
Hôpital Européen Georges-pompidou
France, Paris
Université Paris Cité
Mocumbi, Ana Olga H.
Mozambique, Maputo
Icor
Jani, Dinesh N.
Mozambique, Maputo
Icor
Sidi, Daniel
France, Paris
Université Paris Cité
Mozambique, Maputo
Icor
France, Paris
Hôpital Necker Enfants Malades
Jouven, Xavier P.
France, Paris
Hôpital Européen Georges-pompidou
France, Paris
Université Paris Cité
Australia, Sydney
The University of Sydney School of Medicine
Marijon, Éloi
France, Paris
Hôpital Européen Georges-pompidou
France, Paris
Université Paris Cité
Australia, Sydney
The University of Sydney School of Medicine
Statistics
Citations: 66
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1093/ehjci/jes077
ISSN:
20472404
Research Areas
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Locations
Mozambique