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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive SpragueDawley rats
Pharmaceutical Biology, Volume 50, No. 11, Year 2012
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Description
Context: Annona muricata Linn (Annonaceae) (soursop) is a food plant reported to have antihypertensive properties. Objective: We investigated the blood pressure reducing effect of its aqueous leaf extract and the possible mechanisms that may be responsible. Methods: Intravenous administration of an aqueous leaf extract (9.1748.5 mg/kg) of A. muricata on the mean arterial pressure and heart rate were recorded invasively on anaesthetized, normotensive SpragueDawley rats. Contractile responses of rat aortic rings to the extract (0.54.0 mg/mL) were studied using standard organ bath techniques. Results: A. muricata (9.1748.5 mg/kg) caused significant (p < 0.05) dose-dependent reduction in blood pressure without affecting the heart rates. The hypotensive effects were unaffected by atropine (2 mg/kg), mepyramine (5 mg/kg), propranolol (1 mg/kg) and L-NAME (5 mg/kg). A. muricata leaf aqueous extract significantly (p < 0.05) relaxed phenylephrine (10-910-4 M) and 80 mM KCl induced contractions in endothelium intact and denuded aortic rings; and caused a significant (p < 0.05) rightward shift of the Ca2+ dose response curves in Ca2+-free Kreb's solution containing 0.1 mM EGTA. Conclusions: The hypotensive effects of A. muricata are not mediated through muscarinic, histaminergic, adrenergic and nitric oxide pathways, but through peripheral mechanisms involving antagonism of Ca2+. © 2012 Informa Healthcare USA, Inc.
Authors & Co-Authors
Nwokocha, Chukwuemeka Raphael
Jamaica, Kingston
The University of the West Indies
Owu, Daniel Udofia
Nigeria, Calabar
University of Calabar
Gordon, Angeline
Jamaica, Kingston
The University of the West Indies
Thaxter, Karen A.
Jamaica, Kingston
The University of the West Indies
McCalla, Garsha
Jamaica, Kingston
The University of the West Indies
Ozolua, Raymond Iduojemu
Nigeria, Benin
University of Benin
Young, Lauriann E.
Jamaica, Kingston
The University of the West Indies
Statistics
Citations: 64
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.3109/13880209.2012.684690
ISSN:
13880209
e-ISSN:
17445116
Research Areas
Food Security
Health System And Policy
Noncommunicable Diseases