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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Identification of a New VP4 Serotype of Human Rotaviruses
Virology, Volume 200, No. 1, Article 71163, Year 1994
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Description
A new VP4 gene allele was identified by sequencing of two rotavirus strains recovered from infants with diarrhea. Strains HAL1166 (a VP7 serotype 8 human rotavirus from Finland) and PA169 (a VP7 serotype 6 human rotavirus from Italy) present 22-43% nucleotide sequence divergence and 14-45% amino acid divergence in the VP4 gene with rotaviruses belonging to various VP4 gene alleles previously reported. Cross-neutralization analysis between PA169 and rotaviruses belonging to the other recognized VP4 (P) serotypes had previously shown that none of them was similar to PA169. Hyperimmune serum prepared against a reassortant with the VP4 gene of strain PA169 and the VP7 gene of serotype 2 strain DS1 failed to neutralize previously recognized human rotavirus VP4 serotypes, indicating that PA169 represents a new VP4 serotype specificity. In addition, one of four neutralizing monoclonal antibodies directed to the VP4 of PA169 was specific for this virus, while three others had very limited cross-reactivity with rotaviruses possessing different VP4s. © 1994 Academic Press. All rights reserved.
Authors & Co-Authors
Gerna, Giuseppe
Italy, Pavia
Università Degli Studi Di Pavia
Sears, Johnna F.
United States, Bethesda
National Institutes of Health Nih
Hoshino, Yatsutaka
United States, Bethesda
National Institutes of Health Nih
Steele, Andrew Duncan
United States, Bethesda
National Institutes of Health Nih
Nakagomi, Osamu
Japan, Akita
Faculty of Medicine
Flores, Jorge
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 50
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1006/viro.1994.1163
ISSN:
00426822
Research Areas
Genetics And Genomics