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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The Global Enteric Multicenter Study (GEMS) of diarrheal disease in infants and young children in developing countries: Epidemiologic and clinical methods of the case/control study
Clinical Infectious Diseases, Volume 55, No. SUPPL. 4, Year 2012
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Description
Background. Diarrhea is a leading cause of illness and death among children aged <5 years in developing countries. This paper describes the clinical and epidemiological methods used to conduct the Global Enteric Multicenter Study (GEMS), a 3-year, prospective, age-stratified, case/control study to estimate the population-based burden, microbiologic etiology, and adverse clinical consequences of acute moderate-to-severe diarrhea (MSD) among a censused population of children aged 0-59 months seeking care at health centers in sub-Saharan Africa and South Asia.Methods. GEMS was conducted at 7 field sites, each serving a population whose demography and healthcare utilization practices for childhood diarrhea were documented. We aimed to enroll 220 MSD cases per year from selected health centers serving each site in each of 3 age strata (0-11, 12-23, and 24-59 months), along with 1-3 matched community controls. Cases and controls supplied clinical, epidemiologic, and anthropometric data at enrollment and again approximately 60 days later, and provided enrollment stool specimens for identification and characterization of potential diarrheal pathogens. Verbal autopsy was performed if a child died. Analytic strategies will calculate the fraction of MSD attributable to each pathogen and the incidence, financial costs, nutritional consequences, and case fatality overall and by pathogen.Conclusions. When completed, GEMS will provide estimates of the incidence, etiology, and outcomes of MSD among infants and young children in sub-Saharan Africa and South Asia. This information can guide development and implementation of public health interventions to diminish morbidity and mortality from diarrheal diseases. © 2012 The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
Authors & Co-Authors
Kotloff, Karen L.
United States, Baltimore
University of Maryland School of Medicine
Blackwelder, William C.
United States, Baltimore
University of Maryland School of Medicine
Nasrin, Dilruba
United States, Baltimore
University of Maryland School of Medicine
Nataro, James Paul
United States, Baltimore
University of Maryland School of Medicine
United States, Charlottesville
University of Virginia School of Medicine
Farag, Tamer H.
United States, Baltimore
University of Maryland School of Medicine
van Eijk, Anna Maria
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Adegbola, Richard A.
Gambia
Medical Research Council Unit United Kingdom
Belgium, Wavre
Glaxosmithkline Pharmaceuticals Sa/nv
Alonso, Pedro Luís
Spain, Barcelona
Universitat de Barcelona
Mozambique, Manhica
Centro de Investigação em Saúde de Manhiça Cism
Breiman, Robert F.
United States, Atlanta
Centers for Disease Control and Prevention
Faruque, Abu Syed Golam
Bangladesh, Dhaka
International Centre for Diarrhoeal Disease Research Bangladesh
Saha, Debasish
Gambia
Medical Research Council Unit United Kingdom
Sow, Samba Ousmane
Mali, Bamako
Centre Pour le Développement Des Vaccins
Sur, Deepika
India, Kolkata
National Institute of Cholera and Enteric Diseases India
Zaidi, Anita Kaniz Mehdi
Pakistan, Karachi
The Aga Khan University
Biswas, Kousick
United States, Washington, D.c.
U.s. Department of Veterans Affairs
Panchalingam, Sandra
United States, Baltimore
University of Maryland School of Medicine
Clemens, John David
South Korea, Seoul
International Vaccine Institute, Seoul
United States, Los Angeles
University of California, Los Angeles
Cohen, Daniel I.
Israel, Tel Aviv-yafo
Tel Aviv University
Glass, Roger I.M.
United States, Bethesda
National Institutes of Health Nih
Mintz, Eric Daniel
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Sommerfelt, Halvor
Norway, Bergen
Universitetet I Bergen
Norway, Oslo
Folkehelseinstituttet
Levine, Myron M.
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 326
Authors: 22
Affiliations: 20
Identifiers
Doi:
10.1093/cid/cis753
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study