Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Definition of the viral targets of protective HIV-1-specific T cell responses
Journal of Translational Medicine, Volume 9, No. 1, Article 208, Year 2011
Notification
URL copied to clipboard!
Description
Background: The efficacy of the CTL component of a future HIV-1 vaccine will depend on the induction of responses with the most potent antiviral activity and broad HLA class I restriction. However, current HIV vaccine designs are largely based on viral sequence alignments only, not incorporating experimental data on T cell function and specificity.Methods: Here, 950 untreated HIV-1 clade B or -C infected individuals were tested for responses to sets of 410 overlapping peptides (OLP) spanning the entire HIV-1 proteome. For each OLP, a "protective ratio" (PR) was calculated as the ratio of median viral loads (VL) between OLP non-responders and responders.Results: For both clades, there was a negative relationship between the PR and the entropy of the OLP sequence. There was also a significant additive effect of multiple responses to beneficial OLP. Responses to beneficial OLP were of significantly higher functional avidity than responses to non-beneficial OLP. They also had superior in-vitro antiviral activities and, importantly, were at least as predictive of individuals' viral loads than their HLA class I genotypes.Conclusions: The data thus identify immunogen sequence candidates for HIV and provide an approach for T cell immunogen design applicable to other viral infections. © 2011 Mothe et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Mothe, Beatriz
Spain, Badalona
Irsicaixa Aids Research Institute-hivacat
Spain, Badalona
Hospital Universitari Germans Trias I Pujol
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Llano, Anuska
Spain, Badalona
Irsicaixa Aids Research Institute-hivacat
Ibarrondo, Javier
Spain, Badalona
Irsicaixa Aids Research Institute-hivacat
Daniels, Marcus G.
United States, Los Alamos
Los Alamos National Laboratory
Miranda, Cristina
Spain, Badalona
Hospital Universitari Germans Trias I Pujol
Zamarreño, Jennifer
Spain, Badalona
Irsicaixa Aids Research Institute-hivacat
Bach, Vanessa
Spain, Badalona
Irsicaixa Aids Research Institute-hivacat
Zuniga, Rosario
Peru, Lima
Asociación Civil Impacta Salud y Educación
Pérez-Álvarez, Susana
Spain, Badalona
Irsicaixa Aids Research Institute-hivacat
Spain, Barcelona
Universitat Politécnica de Catalunya
Berger, Christoph Tobias
United States, Cambridge
Massachusetts Institute of Technology
Puertas, Maria C.
Spain, Badalona
Irsicaixa Aids Research Institute-hivacat
Martínez-Picado, Javier
Spain, Badalona
Irsicaixa Aids Research Institute-hivacat
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Rolland, Morgane M.
United States, Frederick
Mhrp
Farfan, Marilu
Peru, Lima
Asociación Civil Impacta Salud y Educación
Szinger, James J.
United States, Los Alamos
Los Alamos National Laboratory
Hildebrand, William H.
United States, Oklahoma City
Ou Medical Center
Yang, Otto Orlean
United States, Los Angeles
University of California, Los Angeles
Sanchez-Merino, Victor
Spain, Barcelona
Hospital Clinic Barcelona
Brumme, Chanson J.
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Brumme, Zabrina L.
Canada, Vancouver
British Columbia Centre for Excellence in Hiv-aids
Canada, Burnaby
Simon Fraser University
Heckerman, David E.
United States, Redmond
Microsoft Research
Allen, Todd M.
United States, Cambridge
Massachusetts Institute of Technology
Mullins, James I.
United States, Seattle
University of Washington
Gómez, Guadalupe
United States, Seattle
University of Washington
Goulder, Philip Jeremy Renshaw
United Kingdom, Oxford
Nuffield Department of Medicine
South Africa, Durban
University of Kwazulu-natal
Walker, Bruce D.
United States, Cambridge
Massachusetts Institute of Technology
South Africa, Durban
University of Kwazulu-natal
United States, Chevy Chase
Howard Hughes Medical Institute
Gatell, José Mariá A.
Spain, Barcelona
Hospital Clinic Barcelona
Clotet, Bonaventura
Spain, Badalona
Irsicaixa Aids Research Institute-hivacat
Spain, Badalona
Hospital Universitari Germans Trias I Pujol
Korber, Bette T.
United States, Los Alamos
Los Alamos National Laboratory
United States, Santa fe
Santa fe Institute
Sánchez, Jorge L.
Peru, Lima
Asociación Civil Impacta Salud y Educación
Brander, Christian
Spain, Badalona
Irsicaixa Aids Research Institute-hivacat
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Statistics
Citations: 161
Authors: 31
Affiliations: 20
Identifiers
Doi:
10.1186/1479-5876-9-208
e-ISSN:
14795876
Research Areas
Infectious Diseases