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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
Nature Genetics, Volume 53, No. 1, Year 2021
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Description
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84–5.29) for men of European ancestry to 3.74 (95% CI, 3.36–4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14–2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71–0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
Authors & Co-Authors
Conti, David V.
United States, Los Angeles
University of Southern California
Darst, Burcu F.
United States, Los Angeles
University of Southern California
Moss, Lilit C.
United States, Los Angeles
University of Southern California
Saunders, Edward J.
United Kingdom, London
The Institute of Cancer Research
Sheng, Xin
United States, Los Angeles
University of Southern California
Chou, Alisha J.
United States, Los Angeles
University of Southern California
Schumacher, Fredrick R.
United States, Cleveland
Case Western Reserve University
United States, Cleveland
University Hospitals Case Medical Center
Al Olama, Ali Amin
United Kingdom, Cambridge
University of Cambridge
Benlloch, Sara
United Kingdom, Cambridge
University of Cambridge
Dadaev, Tokhir
United Kingdom, London
The Institute of Cancer Research
Brook, Mark N.
United Kingdom, London
The Institute of Cancer Research
Sahimi, Ali
United States, Los Angeles
University of Southern California
Hoffmann, Thomas J.
United States, San Francisco
University of California, San Francisco
Takahashi, Atsushi
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Japan, Suita
National Cerebral and Cardiovascular Center
Matsuda, Koichi
Japan, Tokyo
The University of Tokyo
Japan, Tokyo
Biobank
Momozawa, Yukihide
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Muir, Kenneth Ross
United Kingdom, Manchester
The University of Manchester
United Kingdom, Coventry
University of Warwick
Lophatananon, Artitaya
United Kingdom, Manchester
The University of Manchester
Wan, Peggy C.
United States, Los Angeles
University of Southern California
Le Marchand, Loic̈
United States, Honolulu
University of Hawaiʻi Cancer Center
Wilkens, Lynne Ross
United States, Honolulu
University of Hawaiʻi Cancer Center
Stevens, Victoria L.
United States, Kennesaw
American Cancer Society
Gapstur, Susan M.
United States, Kennesaw
American Cancer Society
Carter, Brian D.
United States, Kennesaw
American Cancer Society
Schleutker, Johanna
Finland, Turku
Turun Yliopisto
Finland, Turku
Turun Yliopistollinen Keskussairaala
Tammela, Teuvo L.J.
Finland, Tampere
Tampere University
Sipeky, Csilla
Finland, Turku
Turun Yliopisto
Auvinen, Anssi Pekka
Finland, Tampere
Tampere University
Giles, Graham G.
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Australia, Clayton
Monash Health
Southey, Melissa Caroline
Australia, Clayton
Monash Health
MacInnis, Robert Jeffrey
Australia, East Melbourne
Cancer Council Victoria
Australia, Melbourne
University of Melbourne
Cybulski, Cezary
Poland, Szczecin
Pomeranian Medical University in Szczecin
Wokołorczyk, Dominika
Poland, Szczecin
Pomeranian Medical University in Szczecin
Lubiński, Jan
Poland, Szczecin
Pomeranian Medical University in Szczecin
Neal, David E.
United Kingdom, Oxford
University of Oxford
United Kingdom, Cambridge
Addenbrooke's Hospital
United Kingdom, Cambridge
Cancer Research uk Cambridge Institute
Donovan, Jenny L.
United Kingdom, Bristol
University of Bristol
Hamdy, Freddie C.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
John Radcliffe Hospital
Martin, Richard Michael
United Kingdom, Bristol
University of Bristol
United Kingdom, Royston
National Institute for Health and Care Research
United Kingdom, Bristol
Mrc Integrative Epidemiology Unit
Nordestgaard, BØrge Grønne
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Copenhagen University Hospital
Nielsen, Sune Fallgaard
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Copenhagen University Hospital
Weischer, Maren
Denmark, Copenhagen
Copenhagen University Hospital
Bojesen, Stig Egil
Denmark, Copenhagen
Københavns Universitet
Denmark, Copenhagen
Copenhagen University Hospital
Røder, Andreas
Denmark, Copenhagen
Copenhagen University Hospital
Iversen, Peter
Denmark, Copenhagen
Copenhagen University Hospital
Batra, Jyotsna
Australia, Brisbane
Australian Prostate Cancer Research Centre – Queensland
Australia, Woolloongabba
Translational Research Institute Australia
Chambers, Suzanne K.
Australia, Sydney
University of Technology Sydney
Moya, Leire
Australia, Brisbane
Australian Prostate Cancer Research Centre – Queensland
Australia, Woolloongabba
Translational Research Institute Australia
Horvath, Lisa G.
Australia, Sydney
Chris O'brien Lifehouse
Australia, Sydney
Garvan Institute of Medical Research
Clements, Judith Ann
Australia, Brisbane
Australian Prostate Cancer Research Centre – Queensland
Australia, Woolloongabba
Translational Research Institute Australia
Tilley, Wayne D.
Australia, Adelaide
The University of Adelaide
Risbridger, Gail Petuna
Australia, Clayton
Monash University
Australia, Melbourne
Peter Maccallum Cancer Centre
Grönberg, Henrik
Sweden, Stockholm
Karolinska Institutet
Aly, Markus
Sweden, Stockholm
Karolinska Institutet
Sweden, Stockholm
Karolinska Universitetssjukhuset
Szulkin, Robert
Sweden, Stockholm
Karolinska Institutet
Sweden, Danderyd
Sds Life Science
Eklund, Martin
Sweden, Stockholm
Karolinska Institutet
Nordström, Tobias
Sweden, Stockholm
Karolinska Institutet
Pashayan, Nora
United Kingdom, London
University College London
United Kingdom, Cambridge
University of Cambridge
Dunning, Alison M.
United Kingdom, Cambridge
University of Cambridge
Ghoussaini, Maya
United Kingdom, Hinxton
Wellcome Sanger Institute
Travis, Ruth C.
United Kingdom, Oxford
University of Oxford
Key, Timothy J.
United Kingdom, Oxford
University of Oxford
Riboli, Elio B.
United Kingdom, London
Imperial College London
Park, Jong-yun
United States, Tampa
Moffitt Cancer Center
Sellers, Thomas
United States, Tampa
Moffitt Cancer Center
Lin, Huiyi
United States, New Orleans
Lsu Health Sciences Center - new Orleans
Albanes, Demetrius
United States, Bethesda
National Institutes of Health Nih
Weinstein, Stephanie J.
United States, Bethesda
National Institutes of Health Nih
Mucci, Lorelei Ann
United States, Boston
Harvard T.h. Chan School of Public Health
Giovannucci, Edward Luciano
United States, Boston
Harvard T.h. Chan School of Public Health
Lindstrom̈, Sara
United States, Seattle
University of Washington
Kraft, Peter
United States, Boston
Harvard T.h. Chan School of Public Health
Hunter, David John
United Kingdom, Oxford
University of Oxford
Penney, Kathryn L.
United States, Boston
Harvard Medical School
Turman, Constance
United States, Boston
Harvard T.h. Chan School of Public Health
Tangen, Catherine M.
United States, Seattle
Fred Hutchinson Cancer Center
Goodman, Phyllis J.
United States, Seattle
Fred Hutchinson Cancer Center
Thompson, Ian Murchie
United States, San Antonio
Christus Santa Rosa Hospital
Hamilton, Robert James
Canada, Toronto
Princess Margaret Cancer Centre
Canada, Toronto
University of Toronto
Fleshner, Neil Eric
Canada, Toronto
Princess Margaret Cancer Centre
Finelli, Antonio
Canada, Toronto
Princess Margaret Cancer Centre
Parent, Marie Élise
Canada, Quebec
Institut National de la Recherche Scientifique
Canada, Montreal
University of Montreal
Stanford, Janet L.
United States, Seattle
Fred Hutchinson Cancer Center
United States, Seattle
University of Washington
Ostrander, Elaine A.
United States, Bethesda
National Institutes of Health Nih
Geybels, Milan S.
United States, Seattle
Fred Hutchinson Cancer Center
Koutros, Stella
United States, Bethesda
National Institutes of Health Nih
Beane-Freeman, Laura E.
United States, Bethesda
National Institutes of Health Nih
Stampfer, Meir J.
United States, Boston
Harvard Medical School
Wolk, Alicja
Sweden, Stockholm
Karolinska Institutet
Sweden, Uppsala
Uppsala Universitet
Håkansson, Niclas N.
Sweden, Stockholm
Karolinska Institutet
Andriole, Gerald L.
United States, St. Louis
Washington University School of Medicine in St. Louis
Hoover, Robert N.
United States, Bethesda
National Institutes of Health Nih
MacHiela, Mitchell J.
United States, Bethesda
National Institutes of Health Nih
Sørensen, Karina Dalsgaard Dalsgaard
Denmark, Aarhus
Aarhus Universitetshospital
Denmark, Aarhus
Aarhus Universitet
Borre, Michael
Denmark, Aarhus
Aarhus Universitet
Denmark, Aarhus
Aarhus Universitetshospital
Blot, William James
United States, Nashville
Vanderbilt University Medical Center
United States, Rockville
International Epidemiology Institute
Zheng, Wei
United States, Nashville
Vanderbilt University Medical Center
Yeboah, Edward D.
Ghana, Accra
University of Ghana
Ghana, Accra
Korle bu Teaching Hospital
Mensah, James Edward
Ghana, Accra
University of Ghana
Ghana, Accra
Korle bu Teaching Hospital
Lu, Yongjie
United Kingdom, London
Queen Mary University of London
Thibodeau, Stephen N.
United States, Rochester
Mayo Clinic
McDonnell, Shannon K.
United States, Rochester
Mayo Clinic
Schaid, Daniel J.
United States, Rochester
Mayo Clinic
West, Catharine Mary Louise
United Kingdom, Manchester
Health Innovation Manchester
Burnet, Neil Gunn
United Kingdom, Manchester
Health Innovation Manchester
Maier, Christiane
Germany, Tubingen
Humangenetik Tuebingen
Luedeke, Manuel
Unknown Affiliation
Kibel, Adam S.
United States, Boston
Brigham and Women's Hospital
Drake, Bettina Fisher
United States, St. Louis
Washington University School of Medicine in St. Louis
Cussenot, Olivier
France, Paris
Hôpital Tenon
Cancel-Tassin, Géraldine
France, Paris
Hôpital Tenon
Ménégaux, Florence
France, Villejuif
Institut de Cancerologie Gustave Roussy
Truong, Thérèse
France, Villejuif
Institut de Cancerologie Gustave Roussy
John, Esther M.
United States, Stanford
Stanford University School of Medicine
Grindedal, Eli Marie
Norway, Oslo
Oslo Universitetssykehus
Khaw, Kay Tee T.
United Kingdom, Cambridge
University of Cambridge
Ingles, Sue Ann
United States, Los Angeles
University of Southern California
Stern, Mariana Carla
United States, Los Angeles
University of Southern California
Vega, Ana Karina
Spain, Santiago de Compostela
Fundación Pública Galega de Medicina Xenómica
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
Fachal, Laura
United Kingdom, Cambridge
University of Cambridge
Spain, Santiago de Compostela
Fundación Pública Galega de Medicina Xenómica
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
Rosenstein, Barry S.
United States, New York
Icahn School of Medicine at Mount Sinai
Ostrer, Harry
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Teixeira, Manuel Rodrigues
Portugal, Porto
Instituto Português de Oncologia do Porto fg
Portugal, Porto
Universidade do Porto
Paulo, Paula
Portugal, Porto
Instituto Português de Oncologia do Porto fg
Watya, Stephen
Uganda, Kampala
Uro Care
Lubwama, Alexander
Uganda, Kampala
Uro Care
Bensen, Jeannette T.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Fontham, Elizabeth T.H.
United States, Bethesda
National Institutes of Health Nih
Mohler, James L.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
United States, Buffalo
Roswell Park Cancer Institute
Taylor, Jack A.
United States, Research Triangle Park
National Institute of Environmental Health Sciences Niehs
Kogevinas, Manolis
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Barcelona
Institut Municipal D'investigacio Medica
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Llorca-Díaz, Javier Francisco
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Spain, Santander
Universidad de Cantabria
Castaño-Vinyals, Gemma
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Barcelona
Institut Municipal D'investigacio Medica
Spain, Barcelona
Universitat Pompeu Fabra Barcelona
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Cannon-Albright, Lisa Anne
United States, Salt Lake City
University of Utah School of Medicine
United States
Va Medical Center
Teerlink, Craig Carl
United States, Salt Lake City
University of Utah School of Medicine
United States
Va Medical Center
Huff, Chad D.
United States, Houston
The University of Texas Md Anderson Cancer Center
Strom, Sara S.
United States, Houston
The University of Texas Md Anderson Cancer Center
Multigner, Luc
France, Rennes
Institut de Recherche en Santé, Environnement et Travail
Blanchet, Pascal
France, Rennes
Institut de Recherche en Santé, Environnement et Travail
Brureau, Laurent
France, Rennes
Institut de Recherche en Santé, Environnement et Travail
Kaneva, Radka
Bulgaria, Sofia
Medical University of Sofia
Mitev, Vanio Ivanov
Bulgaria, Sofia
Medical University of Sofia
Leach, Robin J.
United States, San Antonio
University of Texas Health Science Center at San Antonio
Brenner, Hermann
Germany, Heidelberg
German Cancer Research Center
Holleczek, Bernd
Germany, Saarbrucken
Saarland Cancer Registry
Saum, Kai Uwe
Germany, Heidelberg
German Cancer Research Center
Klein, Eric A.
United States, Cleveland
Cleveland Clinic Foundation
Hsing, Ann Wu
United States, Stanford
Stanford University School of Medicine
Kittles, Rick A.
United States, Duarte
City of Hope National Med Center
Murphy, Adam Bryant
United States, Evanston
Northwestern University
Logothetis, Christopher J.
United States, Houston
The University of Texas Md Anderson Cancer Center
Floris, Giuseppe L.
United States, Duarte
City of Hope National Med Center
Steele, Linda
United States, Duarte
City of Hope National Med Center
Ding, Yuanchun
United States, Duarte
City of Hope National Med Center
Isaacs, William B.
United States, Baltimore
Johns Hopkins Medicine
Nemesure, Barbara Berger
United States, Stony Brook
Stony Brook University
Hennis, Anselm J.M.
United States, Stony Brook
Stony Brook University
Jamaica, Kingston
The University of the West Indies
Carpten, John David
United States, Los Angeles
University of Southern California
Pandha, Hardev S.
United Kingdom, Guildford
University of Surrey
Michael, Agnieszka
United Kingdom, Guildford
University of Surrey
de Ruyck, Kim
Belgium, Ghent
Universiteit Gent
Ost, Piet
Belgium, Ghent
Universitair Ziekenhuis Gent
Xu, Jianfeng
United States, Evanston
Northshore University Healthsystem
Razack, Azad Hassan Abdul
Malaysia, Kuala Lumpur
Universiti Malaya
Teo, Soo Hwang
Unknown Affiliation
Newcomb, Lisa F.
United States, Seattle
University of Washington
Lin, Daniel Wei
United States, Seattle
University of Washington
Fowke, Jay H.
United States, Memphis
University of Tennessee Health Science Center
Neslund-Dudas, Christine M.
United States, Detroit
Henry Ford Hospital
Rybicki, Benjamin A.
United States, Detroit
Henry Ford Hospital
Gamulin, Marija
Croatia, Zagreb
Kbc Zagreb
Lessel, Davor
Germany, Hamburg
Universitätsklinikum Hamburg-eppendorf
Usmani, Nawaid H.
Canada, Edmonton
Cross Cancer Institute
Parliament, Matthew B.
Canada, Edmonton
Cross Cancer Institute
Claessens, Frank
Belgium, Leuven
Molecular Endocrinology Laboratory
Joniau, Steven G.
Belgium, Leuven
Ku Leuven– University Hospital Leuven
Gago-Dominguez, Manuela
Spain, Santiago de Compostela
Instituto de Investigación Sanitaria de Santiago de Compostela
United States, La Jolla
University of California, San Diego
Castelao, Jose Esteban
Spain, Vigo
Complejo Hospitalario Universitario de Vigo
Martínez, María Elena Peña
United States, La Jolla
Moores Cancer Center
Townsend, Paul A.
United Kingdom, Guildford
University of Surrey
Bush, William S.
United States, Cleveland
Case Western Reserve University
Aldrich, Melinda C.
United States, Nashville
Vanderbilt University Medical Center
Crawford, Dana C.
United States, Cleveland
Case Western Reserve University
Srivastava, Shiv K.
United States, Bethesda
Uniformed Services University of the Health Sciences
Cullen, Jennifer C.
United States, Bethesda
Uniformed Services University of the Health Sciences
Petrovics, György
United States, Bethesda
Uniformed Services University of the Health Sciences
Casey, Graham
United States, Charlottesville
University of Virginia
Roobol, Monique J.
Netherlands, Rotterdam
Erasmus Mc
Van Schaik, Ron Hn
Netherlands, Rotterdam
Erasmus Mc
Hu, Jennifer J.
United States, Miami
University of Miami Leonard M. Miller School of Medicine
Sanderson, Maureen
United States, Nashville
Meharry Medical College
Varma, Rohit
United States, Los Angeles
Hollywood Presbyterian Medical Center
McKean-Cowdin, Roberta
United States, Los Angeles
University of Southern California
Torres, Mina
United States, Los Angeles
Hollywood Presbyterian Medical Center
Mancuso, Nicholas
United States, Los Angeles
University of Southern California
Berndt, Sonja I.
United States, Bethesda
National Institutes of Health Nih
van den Eeden, Stephen K.
United States, Oakland
Kaiser Permanente Division of Research
United States, San Francisco
University of California, San Francisco
Easton, Douglas F.
United Kingdom, Cambridge
University of Cambridge
Chanock, Stephen J.
United States, Bethesda
National Institutes of Health Nih
Cook, Michael Blaise
United States, Bethesda
National Institutes of Health Nih
Wiklund, Fredrik E.
Sweden, Stockholm
Karolinska Institutet
Nakagawa, Hidewaki
Japan, Yokohama
Riken Center for Integrative Medical Sciences
Witte, John S.
United States, San Francisco
University of California, San Francisco
Eeles, Rosalind A.
United Kingdom, London
The Institute of Cancer Research
United Kingdom, London
The Royal Marsden Nhs Foundation Trust
Kóte-Jarai, Zsofia S.
United Kingdom, London
The Institute of Cancer Research
Haiman, Christopher A.
United States, Los Angeles
University of Southern California
Statistics
Citations: 187
Authors: 205
Affiliations: 137
Identifiers
Doi:
10.1038/s41588-020-00748-0
ISSN:
10614036
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Systematic review
Participants Gender
Male