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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Responses to malarial antigens are altered in helminth-infected children
Journal of Infectious Diseases, Volume 199, No. 10, Year 2009
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Description
Malaria and helminth infections often coincide in the same tropical regions. Studies of the consequences of helminth and malaria coinfection in humans have been few and are mainly epidemiological, with little information on cellular immune responses. In this study, we investigated the antimalarial immune responses of Ghanaian children living in a rural area with a high prevalence of both helminth infection and Plasmodium falciparum infection. Whole blood specimens were cultured with P. falciparum-infected red blood cells (iRBCs), and proand anti-inflammatory cytokines and immune regulatory molecules were measured. In response to iRBCs, levels of interleukin (IL)-10, but not tumor necrosis factor-γ,were higher in samples from helminth-infected children than in those from uninfected children, as was expression of the regulatory molecules suppressor of cytokine signaling (SOCS)-3, Foxp3, and programmed death (PD)-1. Furthermore, a significant correlation was found between SOCS-3 gene expression and IL-10 production. These results indicate that the presence of helminth infection modulates the immune response to malarial parasites, making it more anti-inflammatory. © 2009 by the Infectious Diseases Society of America.
Authors & Co-Authors
Hartgers, Franca C.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Obeng, Benedicta Baffoah
Netherlands, Leiden
Leids Universitair Medisch Centrum
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Kruize, Yvonne C.M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Dijkhuis, Annemiek
Netherlands, Leiden
Leids Universitair Medisch Centrum
McCall, Matthew B.B.
Netherlands, Nijmegen
Radboud University Medical Center
Sauerwein, Robert W.
Netherlands, Nijmegen
Radboud University Medical Center
Luty, A. J.F.
Netherlands, Nijmegen
Radboud University Medical Center
Boakye, Daniel Adjei
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Yazdanbakhsh, Maria M.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Statistics
Citations: 93
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1086/598687
ISSN:
00221899
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study