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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Who is the best hematopoietic stem-cell donor for a male patient with acute leukemia?
Transplantation, Volume 98, No. 5, Year 2014
Notification
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Description
BACKGROUND: Female donors for male recipients worsen the outcome of allogeneic hematopoietic stem-cell transplantation. We wanted to find out whether a male human leukocyte antigen (HLA)-matched unrelated donor (MUD, 8/8, n=2,014) might be an alternative to a female HLA-identical sibling donor (n=2,656) for male patients with acute leukemia. METHODS: This is a retrospective analysis from the Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation. RESULTS: The relative risk (RR) of acute graft-versus-host disease (GVHD) of grades II to IV was increased in the MUD group with acute myeloid leukemia (AML) (RR, 1.47; P<0.001) and acute lymphoblastic leukemia (ALL) (RR, 1.76; P<0.001). There was no difference in incidence of chronic GVHD and nonrelapse mortality between the two groups. Probability of relapse was lower in the MUD group than in the sibling group in patients with ALL (hazards ratio [HR], 0.75; P=0.04) but not in the AML patients (HR, 0.89; P=0.17). Survival was not different between the groups. Leukemia-free survival (LFS) was also similar in the sibling and MUD groups in patients with AML (HR, 1.01; P=0.81) or ALL (HR, 0.93; P=0.45). Factors significantly associated with reduced LFS included active disease, poor cytogenetics, age, year of hematopoietic stem-cell transplantation, reduced-intensity conditioning, and the use of antithymocyte globulin. CONCLUSION: Male patients who received grafts from male MUDs demonstrated an increased incidence of acute GVHD and LFS same as when using HLA-identical female donors. © 2014 by Lippincott Williams and Wilkins.
Authors & Co-Authors
Ringdén, Oolle T.H.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Labopin, Myriam
Unknown Affiliation
Solders, Martin
Sweden, Stockholm
Karolinska Universitetssjukhuset
Beelen, Dietrich Wilhelm
Germany, Essen
Universitätsklinikum Essen
Arnold, Renate
Germany, Berlin
Charité – Universitätsmedizin Berlin
Ehninger, Gerhard E.
Germany, Dresden
Universitätsklinikum Carl Gustav Carus Dresden
Milpied, Noël Jean
France, Talence
Centre Hospitalier Universitaire de Bordeaux
Niederwieser, Dietger
Germany, Leipzig
Universitätsklinikum Leipzig Und Medizinische Fakultät
Hamladji, Rose Marie
Algeria, Algiers
Centre Pierre et Marie Curie
Kyrcz-Krzemien, Slawomira
Poland, Katowice
Slaski Uniwersytet Medyczny w Katowicach
Ganser, Arnold
Germany, Hannover
Hannover Medical School
Socié, Gérard A.
France, Paris
Bmt
Stelljes, Matthias
Germany, Munster
University of Münster
Volin, Liisa
Finland, Helsinki
Helsinki University Hospital
Craddock, Charles F.
United Kingdom, Birmingham
Queen Elizabeth Hospital Birmingham
Mohty, Mohamad
Unknown Affiliation
Statistics
Citations: 16
Authors: 16
Affiliations: 13
Identifiers
Doi:
10.1097/TP.0000000000000102
ISSN:
00411337
Research Areas
Health System And Policy
Study Design
Cohort Study
Participants Gender
Male
Female