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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Overcoming biological, behavioral, and structural vulnerabilities: New directions in research to decrease HIV transmission in men who have sex with men
Journal of Acquired Immune Deficiency Syndromes, Volume 63, No. SUPPL. 2, Year 2013
Notification
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Description
Men who have sex with men (MSM), including transgender women, comprise a heterogeneous group of individuals whose sexual behaviors and gender identities may vary widely between cultures and among individuals. Their sources of increased vulnerability to HIV are diverse, including the increased efficiency of HIV transmission via unprotected anal intercourse, sexual role versatility, asymptomatic sexually transmitted infections, and behavioral factors that may be associated with condomless sex with multiple partners. Societal stigmatization of homosexual behavior and gender nonconformity may result in internalized negative feelings that lead to depression, other affective disorders, and substance use, which in turn are associated with increased risk-taking behaviors. Social stigma and punitive civil environments may lead to delays in seeking HIV and sexually transmitted disease screening, and later initiation of antiretroviral therapy. The iPrEX study demonstrated that chemoprophylaxis can decrease HIV acquisition in MSM, and the HIV prevention trials network 052 study established the biological plausibility that earlier initiation of highly active antiretroviral therapy can decrease HIV transmission to uninfected partners. Despite these advances, MSM remain among the most significantly HIV-affected population in resource-rich and limited settings. New studies will integrate enhanced understanding of the biology of enhanced rectal transmission of HIV and the focused use of antiretrovirals for prevention with culturally tailored approaches that address the potentiating social and behavioral factors associated with enhanced HIV spread among MSM. Copyright © 2013 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Mayer, Kenneth H.
United States, Boston
Harvard Medical School
United States, Boston
Beth Israel Deaconess Medical Center
Wheeler, Darrell P.
United States, Chicago
Loyola University Chicago
Bekker, Linda-Gail Gail
South Africa, Cape Town
University of Cape Town
Grinsztejn, Beatriz Gilda Jegerhorn
Brazil, Rio de Janeiro
Fundacao Oswaldo Cruz
Remien, Robert H.
United States, New York
Vagelos College of Physicians and Surgeons
United States, New York
New York State Psychiatric Institute
Sandfort, Theo G.M.
United States, New York
New York State Psychiatric Institute
Beyrer, Chris C.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
Statistics
Citations: 69
Authors: 7
Affiliations: 8
Identifiers
Doi:
10.1097/QAI.0b013e318298700e
ISSN:
15254135
Research Areas
Infectious Diseases
Mental Health
Sexual And Reproductive Health
Substance Abuse
Study Design
Cross Sectional Study
Participants Gender
Male
Female