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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The use of low‐dose prednisone and melphalan in the treatment of poor‐risk patients with multiple myeloma
Medical and Pediatric Oncology, Volume 1, No. 3, Year 1975
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Description
A study was designed to evaluate the effectiveness of prednisone therapy in poor‐risk patients with multiple myeloma. Patients were treated with melphalan alone or in combination with prednisone at doses of either 0.6 mg/kg or 0.3 mg/ kg. The group of patients receiving melphalan and prednisone 0.6 mg/kg had significantly improved responses in hemoglobin, lowering of the M‐protein concentration, and reduction of azotemia. Significant benefits attributable to prednisone were not demonstrated in the group receiving 0.3 mg/kg. Good responses have been shown to produce improved survival. The combination of melphalan and prednisone is effective in producing good responses, but the dose of steroids is important. A dose of prednisone of 0.6 mg/kg in gradually decreasing doses has been found to be effective in production of good responses, especially in the uremic patient. Copyright © 1975 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Cuttner, Janet
United States, New York
Icahn School of Medicine at Mount Sinai
Wasserman, Louis Robert
United States, New York
Icahn School of Medicine at Mount Sinai
Martz, Georges
Switzerland, Zurich
Universität Zürich
Sonntag, Roland W.
Switzerland, Bern
University of Bern
Kyle, Robert A.
United States, Rochester
Mayo Clinic
Silver, Richard T.
United States, New York
New York Presbyterian Hospital
Spurr, Charles L.
United States, Winston Salem
Wake Forest University School of Medicine
Harley, John B.
United States, Morgantown
West Virginia University School of Medicine Morgantown
Wiernik, Peter H.
United States, Rockville
National Cancer Institute Nci
Cornwell, Gibbons G.
United States, Hanover
Geisel School of Medicine at Dartmouth
Falkson, Geoffrey G.
South Africa, Pretoria
Steve Biko Academic Hospital
Glidewell, Oliver J.
Unknown Affiliation
Holland, James F.W.
Unknown Affiliation
Statistics
Citations: 13
Authors: 13
Affiliations: 12
Identifiers
Doi:
10.1002/mpo.2950010304
ISSN:
00981532
e-ISSN:
1096911X
Research Areas
Health System And Policy