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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Three cases of invasive meningococcal disease caused by a capsule null locus strain circulating among healthy carriers in Burkina Faso
Journal of Infectious Diseases, Volume 195, No. 7, Year 2007
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Description
During reinforced surveillance of acute bacterial meningitis in Burkina Faso, meningococcal strains of phenotype NG:NT:NST were isolated from cerebrospinal fluid samples from 3 patients. The strains were negative for the ctrA gene but were positive for the crgA gene. Molecular typing revealed that the strains harbored the capsule null locus (cnl) and belonged to the multilocus sequence type (ST)-192. PorA sequencing showed that all strains were either P1.18-11,42; P1.18,42-1; P1.18-11,42-1; P1.18-11,42-3; or P1.18-12,42-1. Sequencing also showed that all strains were negative for the FetA receptor gene. Serum killing assays showed these strains to be resistant, with the resistance comparable with that of a fully capsular serogroup B strain, MC58. The same strains were found in 14 healthy carriers in the general population of Bobo-Dioulasso (100% of ST-192 isolates tested for cnl). The presence of cnl meningococci that can escape serum killing and cause invasive disease is of concern for future vaccination strategies and should promote rigorous surveillance of cnl meningococcal disease. © 2007 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Findlow, Helen
United Kingdom, London
Public Health England
United Kingdom, Manchester
Manchester Royal Infirmary
Vogel, Ulrich
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Mueller, Judith E.
France, Paris
Agence de Médecine Préventive
Curry, Alan
United Kingdom, London
Public Health England
Njanpop-Lafourcade, Berthe Marie
France, Paris
Agence de Médecine Préventive
Claus, Heike
Germany, Wurzburg
Julius-maximilians-universität Würzburg
Gray, Stephen J.
United Kingdom, London
Public Health England
Yaro, Seydou
Burkina Faso, Ouagadougou
Centre Muraz
Traoré, Yves
Burkina Faso, Ouagadougou
University of Ouagadougou
Sangaré, Lassana
Burkina Faso, Ouagadougou
Centre Hospitalier Universitaire Yalgado Ouedraogo
Nicolas, Pierre
Switzerland, Geneva
Organisation Mondiale de la Santé
Gessner, Bradford D.
France, Paris
Agence de Médecine Préventive
Borrow, Ray
United Kingdom, London
Public Health England
Statistics
Citations: 64
Authors: 13
Affiliations: 8
Identifiers
Doi:
10.1086/512084
ISSN:
00221899
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Burkina Faso