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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers
Movement Disorders, Volume 38, No. 4, Year 2023
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Description
Background: Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. Objective: We used results from genome-wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify common genetic risk factors. Methods: We used individual data for participants of European ancestry from the Courage-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease; PD, N = 16,519) and EPITHYR (differentiated thyroid cancer, N = 3527) consortia and summary statistics of GWASs from iPDGC (International Parkinson Disease Genomics Consortium; PD, N = 482,730), Melanoma Meta-Analysis Consortium (MMAC), Breast Cancer Association Consortium (breast cancer), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (prostate cancer), International Lung Cancer Consortium (lung cancer), and Ovarian Cancer Association Consortium (ovarian cancer) (N comprised between 36,017 and 228,951 for cancer GWASs). We estimated the genetic correlation between PD and cancers using linkage disequilibrium score regression. We studied the association between PD and polymorphisms associated with cancers, and vice versa, using cross-phenotypes polygenic risk score (PRS) analyses. Results: We confirmed a previously reported positive genetic correlation of PD with melanoma (Gcorr = 0.16 [0.04; 0.28]) and reported an additional significant positive correlation of PD with prostate cancer (Gcorr = 0.11 [0.03; 0.19]). There was a significant inverse association between the PRS for ovarian cancer and PD (odds ratio [OR] = 0.89 [0.84; 0.94]). Conversely, the PRS of PD was positively associated with breast cancer (OR = 1.08 [1.06; 1.10]) and inversely associated with ovarian cancer (OR = 0.95 [0.91; 0.99]). The association between PD and ovarian cancer was mostly driven by rs183211 located in an intron of the NSF gene (17q21.31). Conclusions: We show evidence in favor of a contribution of pleiotropic genes to the association between PD and specific cancers. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Authors & Co-Authors
Sugier, Pierre Emmanuel
Unknown Affiliation
Lucotte, Elise A.
Unknown Affiliation
Domenighetti, Cloe
Unknown Affiliation
Law, Matthew H.
Unknown Affiliation
Iles, Mark Martin
Unknown Affiliation
Brown, Kevin M.
Unknown Affiliation
Amos, Christopher Ian
Unknown Affiliation
McKay, James D.
Unknown Affiliation
Hung, Rayjean J.
Unknown Affiliation
Karimi, Mojgan
Unknown Affiliation
Bacq-Daian, Delphine
Unknown Affiliation
Boland, Anne
Unknown Affiliation
Olaso, Robert
Unknown Affiliation
Deleuze, Jean François
Unknown Affiliation
Lesueur, Fabienne El Khoury
Unknown Affiliation
Ostroumova, Evgenia
Unknown Affiliation
Kesminiene, Ausrele
Unknown Affiliation
De Vathaire, Florent
Unknown Affiliation
Guénel, Pascal
Unknown Affiliation
Sreelatha, Ashwin Ashok Kumar
Unknown Affiliation
Schulte, Claudia M.S.
Unknown Affiliation
Grover, Sandeep
Unknown Affiliation
May, Patrick
Unknown Affiliation
Bobbili, Dheeraj Reddy
Unknown Affiliation
Radivojkov-Blagojević, Milena
Unknown Affiliation
Lichtner, Peter K.
Unknown Affiliation
Singleton, Andrew B.
Unknown Affiliation
Hernandez, Dena G.
Unknown Affiliation
Edsall, Connor
Unknown Affiliation
Mellick, George D.
Unknown Affiliation
Zimprich, Alexander
Unknown Affiliation
Pirker, Walter
Unknown Affiliation
Rogaeva, Ekaterina A.
Unknown Affiliation
Lang, Anthony E.
Unknown Affiliation
Kõks, Sulev V.
Unknown Affiliation
Taba, Pille
Unknown Affiliation
Lesage, Suzanne
Unknown Affiliation
Brice, Alexis
Unknown Affiliation
Corvol, Jean Christophe
Unknown Affiliation
Chartier-Harlin, Marie Christine
Unknown Affiliation
Mutez, Eugénie
Unknown Affiliation
Brockmann, Kathrin
Unknown Affiliation
Deutschländer, Angela B.
Unknown Affiliation
Hadjigeorgiou, Georgios M.
Unknown Affiliation
Dardiotis, Efthymios
Unknown Affiliation
Stefanis, Leonidas
Unknown Affiliation
Simitsi, Athina Maria
Unknown Affiliation
Valente, Enza Maria
Unknown Affiliation
Petrucci, Simona
Unknown Affiliation
Straniero, Letizia
Unknown Affiliation
Zecchinelli, A. Lena
Unknown Affiliation
Pezzoli, Gianni
Unknown Affiliation
Brighina, Laura
Unknown Affiliation
Ferrarese, Carlo
Unknown Affiliation
Annesi, Grazia
Unknown Affiliation
Quattrone, Andrea
Unknown Affiliation
Gagliardi, Monica
Unknown Affiliation
Matsuo, Hirotaka
Unknown Affiliation
Nakayama, Akiyoshi
Unknown Affiliation
Hattori, Nobutaka
Unknown Affiliation
Nishioka, Kenya
Unknown Affiliation
Chung, Sun-ju
Unknown Affiliation
Kim, Yunjoong
Unknown Affiliation
Kolber, Pierre
Unknown Affiliation
van de Warrenburg, Bart P.C.
Unknown Affiliation
Bloem, Bastiaan R.
Unknown Affiliation
Aasly, Jan Olav
Unknown Affiliation
Toft, Mathias
Unknown Affiliation
Pihlstrom, Lasse
Unknown Affiliation
Guedes, Leonor Correia
Unknown Affiliation
Ferreira, Joaquim José
Unknown Affiliation
Bardien, Soraya
Unknown Affiliation
Carr, Jonathan A.
Unknown Affiliation
Tolosa, Eduardo S.
Unknown Affiliation
Ezquerra, Mario
Unknown Affiliation
Pástor, Pau
Unknown Affiliation
Diez-Fairen, Monica
Unknown Affiliation
Wirdefeldt, Karin
Unknown Affiliation
Pedersen, Nancy Lee
Unknown Affiliation
Ran, Caroline
Unknown Affiliation
Belin, Andrea Carmine
Unknown Affiliation
Puschmann, Andreas J.
Unknown Affiliation
Rödström, Emil Ygland
Unknown Affiliation
Clarke, Carl E.
Unknown Affiliation
Morrison, Karen E.
Unknown Affiliation
Tan, Manuela M.X.
Unknown Affiliation
Krainc, Dimitri
Unknown Affiliation
Burbulla, Lena F.
Unknown Affiliation
Farrer, Matthew J.
Unknown Affiliation
Kruger, Rejko
Unknown Affiliation
Gasser, Thomas
Unknown Affiliation
Sharma, Manu
Unknown Affiliation
Truong, Thérèse
Unknown Affiliation
Elbaz, Alexis
Unknown Affiliation
Statistics
Citations: 94
Authors: 94
Affiliations: 74
Identifiers
Doi:
10.1002/mds.29337
ISSN:
08853185
e-ISSN:
15318257
Research Areas
Cancer
Genetics And Genomics
Study Design
Case-Control Study
Study Approach
Systematic review