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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Characterization of MYC-induced tumorigenesis by in situ lipid profiling
Analytical Chemistry, Volume 85, No. 9, Year 2013
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Description
We apply desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to provide an in situ lipidomic profile of genetically modified tissues from a conditional transgenic mouse model of MYC-induced hepatocellular carcinoma (HCC). This unique, label-free approach of combining DESI-MSI with the ability to turn specific genes on and off has led to the discovery of highly specific lipid molecules associated with MYC-induced tumor onset. We are able to distinguish normal from MYC-induced malignant cells. Our approach provides a strategy to define a precise molecular picture at a resolution of about 200 μm that may be useful in identifying lipid molecules that define how the MYC oncogene initiates and maintains tumorigenesis. © 2013 American Chemical Society.
Authors & Co-Authors
Perry, Richard H.
United States, Palo Alto
Stanford University
United States, Urbana
University of Illinois Urbana-champaign
Bellovin, David I.
United States, Stanford
Stanford University School of Medicine
Shroff, Emelyn H.
United States, Stanford
Stanford University School of Medicine
Ismail, Ali Issa
United States, Palo Alto
Stanford University
Saudi Arabia, Jeddah
King Abdulaziz University
Zabuawala, Tahera
United States, Stanford
Stanford University School of Medicine
Felsher, Dean W.
United States, Stanford
Stanford University School of Medicine
Zare, Richard N.
United States, Palo Alto
Stanford University
Statistics
Citations: 33
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1021/ac400479j
e-ISSN:
15206882
Research Areas
Cancer