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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Comparison of heterologous neutralizing antibody responses of human immunodeficiency virus type 1 (HIV-1)- and HIV-2-infected senegalese patients: Distinct patterns of breadth and magnitude distinguish HIV-1 and HIV-2 infections
Journal of Virology, Volume 81, No. 10, Year 2007
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Description
Neutralizing antibody responses against heterologous isolates in human immunodeficiency virus type 1 (HIV-1) and HIV-2 infections were compared, and their relationships with established clinical markers of progression were examined. Neutralizing responses against 7 heterologous primary isolates and 1 laboratory strain were compared between 32 untreated HIV-1-infected subjects and 35 untreated HIV-2-infected subjects using a pseudotyped reporter virus assay. The breadth of the neutralizing response, defined as the proportion of panel viruses positively neutralized by patient plasma, was significantly greater among HIV-2-infected subjects than among HIV-1-infected subjects. Notably, for fully one-third of HIV-2 subjects, all viruses were effectively neutralized in our panel. Magnitudes of responses, defined as reciprocal 50% inhibitory concentration (IC50) titers for positive reactions, were significantly greater among HIV-1-infected subjects than among HIV-2-infected subjects. When plasma samples from HIV-1 patients were tested for cross-neutralization of HIV-2 and vice versa, we found that these intertype responses are very rare and their prevalences comparable in both HIV-1 and HIV-2 infection. The significantly higher magnitude of heterologous responses for HIV-1 compared to HIV-2 prompted us to examine associations with viremia, which is known to be significantly higher in HIV-1 infection. Importantly, there was a significant positive correlation between the IC50 titer and viral load within both the HIV-1 and HIV-2 groups, suggesting heterologous antibodies may be driven by viral replication. We conclude that HIV-2 infection is characterized by a broad, low-magnitude intratype neutralization response, while HIV-1 is characterized by a narrower but higher-magnitude intratype response and that a significant positive association between the IC50 titer and viremia is common to both HIV-1 and HIV-2 infections. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Rodriguez, Shaun K.
United States, Boston
Harvard T.h. Chan School of Public Health
Sarr, Abdoulaye Dieng
United States, Boston
Harvard T.h. Chan School of Public Health
MacNeil, Adam
United States, Boston
Harvard T.h. Chan School of Public Health
Thakore-Meloni, Seema
United States, Boston
Harvard T.h. Chan School of Public Health
Guéye-Ndiaye, Aïssatou
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Traoré, Ibrahima
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Dia, Mamadou Ciré
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Mboup, Souleymane
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Kanki, Phyllis Jean
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 55
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1128/JVI.02789-06
ISSN:
0022538X
Research Areas
Health System And Policy
Infectious Diseases